Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Florea, A; Morgenroth, A; Bucerius, J; Schurgers, LJ; Mottaghy, FM.
Locking and loading the bullet against micro-calcification
EUR J PREV CARDIOL. 2021; 28(12): 1370-1375.
Doi: 10.1177/2047487320911138
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- Aims Despite recent medical advances, cardiovascular disease remains the leading cause of death worldwide. As (micro)-calcification is a hallmark of atherosclerosis, this review will elaborately discuss advantages of sodium fluoride positron emission tomography (PET) as a reliable cardiovascular imaging technique for identifying the early onset of vascular calcification (i.e. locking onto the target). We assess state-of-the-art meta-analysis and clinical studies of possible treatment options and evaluate the concept of vitamin K supplementation to preserve vascular health (i.e. loading the bullet). Methods and results After a structured PubMed search, we identified F-18-sodium fluoride (F-18-NaF) PET as the most suitable technique for detecting micro-calcification. Presenting the pros and cons of available treatments, vitamin K supplementation should be considered as a possible safe and cost-effective option to inhibit vascular (micro)-calcification. Conclusion This review demonstrates need for more extensive research in the concept of vitamin K supplementation (i.e. loading the bullet) and recommends monitoring the effects on vascular calcification using F-18-NaF PET (i.e. locking onto the target).
- Find related publications in this database (Keywords)
- Vascular calcification
- CAC score
- CT
- F-18-NaF PET
- vitamin K