Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kerl, H; Soyer, HP; Cerroni, L; Wolf, IH; Ackerman, AB.
Ancient melanocytic nevus.
Semin Diagn Pathol. 1998; 15(3):210-215
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- Führende Autor*innen der Med Uni Graz
- Kerl Helmut
- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Soyer Hans Peter
- Wolf Ingrid
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- Abstract:
- Ancient melanocytic nevus is an example of a simulator of malignant melanoma, designated ancient because it shares numerous features with ancient schwannoma. Knowledge of the histopathologic characteristics of this benign melanocytic neoplasm should enable pathologists to avoid overdiagnosis of it as melanoma arising in the intradermal portion of a nevus. Ancient nevi are found most commonly on the face of older persons. The neoplasm is usually a dome-shaped, skin-colored or reddish brown papule, usually with features of a Miescher's nevus. Histopathologically, ancient nevi are exoendophytic, mostly intradermal proliferations of two populations of melanocytes: one with large pleomorphic nuclei and the other with small monomorphous ones. The large melanocytes may resemble those of the epithelioid type of Spitz's nevus. A few mitotic figures may be present in a particular section. The epidermis usually is uninvolved, but sometimes there may be a junctional component. Other important findings are degenerative changes that include thrombi, zones of hemorrhage, pseudoangiomatous changes, thick rims of sclerosis around dilated venules, fibrosis, and mucin. Ancient nevi frequently are misdiagnosed as melanoma arising in an intradermal nevus.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Diagnosis, Differential -
- Diagnostic Errors -
- Face - pathology
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Melanocytes - pathology
- Melanoma - congenital Melanoma - pathology
- Middle Aged -
- Neoplasms, Second Primary - pathology
- Nevus, Pigmented - congenital Nevus, Pigmented - pathology
- Skin Neoplasms - congenital Skin Neoplasms - pathology
- Find related publications in this database (Keywords)
- Ancient Melanocytic Nevus
- Melanoma Within Intradermal Mieschers Nevus
- Benign Simulators of Melanoma