Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bucerius, J; Joe, AY; Herder, E; Brockmann, H; Biermann, K; Palmedo, H; Tiemann, K; Biersack, HJ.
Hemodynamic variables during stress testing can predict referral to early catheterization but failed to show a prognostic impact on emerging cardiac events in patients aged 70 years and older undergoing exercise 99mTc-sestamibi myocardial perfusion scintigraphy
INT J CARDIOVAS IMAG. 2009; 25(6): 569-579.
Doi: 10.1007/s10554-009-9461-2
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- The aim of the present study was to evaluate the prognostic value of hemodynamic variables during ergometric stress testing for Tc-99m-sestamibi myocardial perfusion scintigraphy (MPS) as compared to several patient-related variables and MPS results with regard to referral to early coronary angiography (<3 months after MPS; CA) as well as cardiac event (CE) free survival in a study population aged >= 70 years. About 90 patients aged >= 70 years (74.5 +/- 3.6 years) who underwent ergometric stress/rest MPS were included in this study. About 19 hemodynamic variables during stress testing were assessed. Semiquantitative visual interpretation of MPS images were performed and Summed-Stress(SSS), Summed-Difference-, and Summed-Rest-Scores were calculated. Emerging CE comprised myocardial revascularization and -infarction as well as cardiac-related death. Multivariate logistic regression analyses were performed for evaluation of independent prognostic impact of hemodynamic-, MPS- and clinical-variables with regard to referral to early catheterization as well as emerging CE. Kaplan-Meier survival- and log rank analyses were calculated for assessment of CE free survival. History of CAD (Odds ratio; OR: 99.3), low rest heart rate (OR: 14.9) and low peak systolic blood pressure (OR: 15.4) during ergometric stress testing as well as pathological SSS (OR: 48.4) were significantly associated with referral to CA. History of ischemic ECG (OR: 4.7) and pathological SSS (OR: 3.7) independently predicted emerging CE and were associated with a lower CE free survival. In patients aged >= 70 years, CA is independently predicted by clinical variables, pathological results of MPS and hemodynamic variables. In contrast, hemodynamic response to stress testing failed to show any predictive impact on emerging CE.
- Find related publications in this database (Keywords)
- Coronary artery disease
- Elderly
- Tc-99m-sestamibi myocardial perfusion scintigraphy
- Hemodynamic variables
- Cardiac related outcome