Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
De Saint-Hubert, M; Bauwens, M; Deckers, N; Drummen, M; Douma, K; Granton, P; Hendrikx, G; Kusters, D; Bucerius, J; Reutelingsperger, CPM; Mottaghy, FM.
In Vivo Molecular Imaging of Apoptosisand Necrosis in Atherosclerotic PlaquesUsing MicroSPECT-CT and MicroPET-CT Imaging
MOL IMAGING BIOL. 2014; 16(2): 246-254.
Doi: 10.1007/s11307-013-0677-0
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- The purpose of this paper is to study molecular imaging of apoptosis and necrosis, two key players in atherosclerosis instability, using a multimodal imaging approach combining single photon emission computed tomography (SPECT), positron emission tomography (PET), and computed tomography (CT). Collar-induced carotid atherosclerosis ApoE knockout mice were imaged with Tc-99m-AnxAF568 SPECT-CT to study apoptosis and sequentially with PET-CT following I-124-Hypericin (I-124-Hyp) injection to visualize necrosis. SPECT depicted increased Tc-99m-AnxAF568 uptake in both atherosclerotic carotid arteries, whereas our data suggest that this uptake is not merely apoptosis related. Although PET of I-124-Hyp was hampered by the slow blood clearance in atherosclerotic mice, I-124-Hyp was able to target necrosis in the atherosclerotic plaque. Both Tc-99m-AnxAF568 and I-124-Hyp uptake are increased in atherosclerotic carotid vasculature compared to control arteries. While apoptosis imaging remains challenging, necrosis imaging can be feasible after improving the biodistribution characteristics of the probe.
- Find related publications in this database (Keywords)
- Apoptosis
- Necrosis
- Molecular imaging
- Atherosclerosis