Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Boswijk, E; Sanders, KJC; Broeders, EPM; de Ligt, M; Vijgen, GHEJ; Havekes, B; Mingels, AMA; Wierts, R; Lichtenbelt, WDV; Schrauwen, P; Mottaghy, FM; Wildberger, JE; Bucerius, J.
TSH suppression aggravates arterial inflammation an 18F-FDG PET study in thyroid carcinoma patients
EUR J NUCL MED MOL I. 2019; 46(7): 1428-1438.
Doi: 10.1007/s00259-019-04292-w
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Bucerius Jan Alexander
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- Abstract:
- PurposeWe aimed to investigate the influence of both hypothyroidism and thyroid-stimulating hormone (TSH) suppression on vascular inflammation, as assessed with F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET)/computed tomography (CT).MethodsTen thyroid carcinoma patients underwent an F-18-FDG PET/CT during post-thyroidectomy hypothyroidism and during thyrotropin (TSH) suppression after I-131 (radioiodine) ablation therapy. We analysed the F-18-FDG uptake in the carotids, aortic arch, ascending, descending, and abdominal aorta to investigate the effects of thyroid hormone status on arterial inflammation. Target-to-background ratios (TBRs) corrected for blood pool activity were established for all arterial territories. Results were further compared to euthyroid historic control subjects.ResultsIn general, there was a trend towards higher vascular TBRs during TSH suppression than during hypothyroidism (TBRmax all vessels=1.6 and 1.8, respectively, p=0.058), suggesting a higher degree of arterial inflammation. In concurrence with this, we found increased C-reactive protein (CRP) levels after levothyroxine treatment (CRP=2.9mg/l and 4.8mg/l, p=0.005). An exploratory comparison with euthyroid controls showed significant higher TBRs during TSH suppression for the carotids, aortic arch, thoracic descending aorta, and when all vascular territories were combined (TBR(max)p=0.013, p=0.016, p=0.030 and p=0.018 respectively).ConclusionsArterial inflammation is increased during TSH suppression. This finding sheds new light on the underlying mechanism of the suspected increased risk of cardiovascular disease in patients with TSH suppression.
- Find related publications in this database (Keywords)
- Positron emission tomography (PET)
- Thyroid disease
- Atherosclerosis
- Inflammation
- TSH suppression