Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Truijman, MTB; Kwee, RM; van Hoof, RHM; Hermeling, E; van Oostenbrugge, RJ; Mess, WH; Backes, WH; Daemen, MJ; Bucerius, J; Wildberger, JE; Kooi, ME.
Combined ¹⁸F-FDG PET-CT and DCE-MRI to Assess Inflammation and Microvascularization in Atherosclerotic Plaques
STROKE. 2013; 44(12): 3568-3570. Doi: 10.1161/STROKEAHA.113.003140
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Bucerius Jan Alexander
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Abstract:: Background and Purpose Hallmarks of vulnerable atherosclerotic plaques are inflammation that can be assessed with (18)fluorine-fluorodeoxyglucose positron emission tomography/computed tomography, and increased neovascularization that can be evaluated by dynamic contrast-enhanced-MRI. It remains unclear whether these parameters are correlated or represent independent imaging parameters. This study determines whether there is a correlation between inflammation and neovascularization in atherosclerotic carotid plaques. Methods A total of 58 patients with transient ischemic attack or minor stroke in the carotid territory and ipsilateral carotid artery stenosis of 30% to 69% were included. All patients underwent positron emission tomography/computed tomography and dynamic contrast-enhanced-MRI of the carotid plaque. (18)Fluorine-fluorodeoxyglucose standard uptake values with target/background ratio were determined. Neovascularization was quantified by the mean (leakage) volume transfer constant K-trans. Spearman rank correlation coefficients between target/background ratio and K-trans were calculated. Results Images suitable for further analysis were obtained in 49 patients. A weak but significant positive correlation between target/background ratio and mean K-trans (Spearman =0.30 [P=0.035]) and 75th percentile K-trans (Spearman =0.29 [P=0.041]) was found. Conclusions There is a weak but significant positive correlation between inflammation on positron emission tomography/computed tomography and neovascularization as assessed with dynamic contrast-enhanced-MRI. Future studies should investigate which imaging modality has the highest predictive value for recurrent stroke, as these are not interchangeable.
Find related publications in this database (Keywords): atherosclerosis; imaging; inflammation; magnetic resonance imaging; neovascularization; plaque; atherosclerotic; positron-emission tomography; vascular diseases