Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Navigation/Suche

• Forscher*innen.
• Institutionen.
• Projekte.
• Publikationen.
• Partner.
• Geldgeber.
• Ausstattung.
• Knowhow.
• Forschungsfelder.

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

de Pont, C; Halders, S; Bucerius, J; Mottaghy, F; Brans, B.
¹²⁴I PET/CT in the pretherapeutic staging of differentiated thyroid carcinoma: comparison with posttherapy ¹³¹I SPECT/CT
EUR J NUCL MED MOL I. 2013; 40(5): 693-700. Doi: 10.1007/s00259-012-2331-5
Web of Science PubMed FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz

Bucerius Jan Alexander

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

To compare pretherapy I-124 PET/CT and posttherapy I-131 SPECT/CT in the identification of pathological lesions and the staging of patients with differentiated thyroid carcinoma. I-124 SPECT with low-dose CT in addition to a standard whole-body scan was performed 5 days following I-131 therapy with the administration of 1,110-7,728 MBq. Pretherapy I-124 PET/CT was done 24 h and 96 h after oral ingestion of 20-28 MBq, including a noncontrast high-dose CT scan. Scans were evaluated by two independent experienced nuclear physicians. In addition to the total number of lesions found, patient-based analyses and lesion-based analyses were performed to ascertain the discrepancies between the findings of the two scanning techniques, as well as to evaluate the clinical impact of the findings. A group of 20 consecutive patients were analysed. In the lesion-based analysis, a total of 62 foci were found with all modalities together. Of these, I-124 PET/CT found 57 (92 %), I-131 SPECT/CT 50 (81 %) and planar imaging 39 (63 %). In the patient-based analysis, in 50 % of patients complete concordance between the findings of I-124 PET and I-131 SPECT was seen, in 5 % complete discordance and in the remaining 45 % partial discordance, i.e. a focus or some foci seen with both modalities but another or others seen more or less with one or other modality. In 5 of the 20 patients (25 %), tumour stage was changed according to the findings of one of the modalities. In 60 % of these patients this was only with the findings of I-124 PET/CT. This study showed that I-124 PET/CT is preferred over I-131 imaging for staging differentiated thyroid carcinoma.

Find related publications in this database (Keywords)

Differentiated thyroid carcinoma

Radioiodine

SPECT/CT

PET/CT

Iodine-124

Iodine-131

© Med Uni Graz • Impressum