Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Navigation/Suche

• Forscher*innen.
• Institutionen.
• Projekte.
• Publikationen.
• Partner.
• Geldgeber.
• Ausstattung.
• Knowhow.
• Forschungsfelder.

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Reinhardt, MJ; Strunk, H; Gerhardt, T; Roedel, R; Jaeger, U; Bucerius, J; Sauerbruch, T; Biersack, HJ; Dumoulin, FL.
Detection of Klatskin's tumor in extrahepatic bile duct strictures using delayed ¹⁸F-FDG PET/CT:: Preliminary results for 22 patient studies
J NUCL MED. 2005; 46(7): 1158-1163.
Web of Science PubMed

 

Co-Autor*innen der Med Uni Graz

Bucerius Jan Alexander

Altmetrics:

Dimensions Citations:

Plum Analytics:

Abstract:

Detection of cholangiocarcinoma in extrahepatic bile duct strictures is a continuing challenge in clinical practice because brush cytology taken at encloscopic retrograde cholangiography has an average sensitivity of 50%. The aim of this study was to evaluate the effectiveness of dual-modality PET/CT using F-18-FDG for noninvasive differentiation of extrahepatic bile duct strictures. Methods: Twenty-two PET/CT studies were performed on 20 patients (10 women, 10 men; mean age +/- SD, 63 +/- 14 y) with extrahepatic bile duct strictures on endoscopic retrograde cholangiography. PET imaging was started 101 +/- 22 min after injection of 369 +/- 48 MBq of F-18-FDG. Blood glucose was 100 +/- 20 mg/dL. PET images were reconstructed iteratively with attenuation correction based on a rescaling of the CT image. CT was performed within 1 min before the PET study, with the patient in the same position. CT was used to place a volume of interest 5 cm in diameter at the liver hilus for quantitative evaluation of PET images by means of standardized uptake values (SUVs). Results: Final diagnosis was histologically proven cholangiocarcinoma in 14 cases and benign causes of strictures in 8 cases without evidence of malignancy during a follow-up of 18 +/- 3 mo. All patients with cholangiocarcinoma presented with focal increased uptake in the liver hilus with an SUV of 6.8 +/- 3.3 (range, 3.9-15.8), compared with 2.9 +/- 0.3 (range, 2.5-3.3) in patients with benign causes of strictures (P = 0.003). There was a clear cutoff SUV of 3.6 for detection of malignancy in the liver hilus. Conclusion: F-18-FDG PET/CT provided high accuracy for noninvasive detection of perihilar cholangiocarcinoma in extrahepatic bile duct strictures.

Find related publications in this database (Keywords)

FDG

PET

CT

cholangiocarcinoma

© Med Uni Graz • Impressum