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SHR Neuro Cancer Cardio Lipid Metab Microb
Betzler, A; Betzler, J; Bogner, A; Walther, E; Rahbari, M; Reissfelder, C; Riediger, C; Weitz, J; Rahbari, NN; Birgin, E.
Long-term diuretic medication is an independent predictor of posthepatectomy liver failure.
J GASTROINTEST SURG. 2025; 29(5): 102035
Doi: 10.1016/j.gassur.2025.102035
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Bogner Andreas Georg
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- Abstract:
- BACKGROUND: Posthepatectomy liver failure (PHLF) is the most fatal complication after liver resection, particularly in patients with comorbidities. This study aimed to assess the effect of long-term medication on PHLF incidence after open liver resections. METHODS: A retrospective analysis of 682 patients who underwent elective open hepatectomies between 2008 and 2015 at 2 academic centers was performed. Preoperative, intraoperative, and postoperative data were collected, including long-term medication. The risk factors for the development of PHLF and other postoperative complications were evaluated using univariate and multivariate logistic regression analyses. RESULTS: PHLF occurred in 81 patients (11.9%), with a higher incidence in patients taking diuretics as long-term medication than in those not taking diuretics (17.7% vs 5.3%, respectively; P <.001). Diuretic use was identified as a strong independent risk factor for PHLF (odds ratio [OR], 3.8 [95% CI, 2.1-7.0]; P <.001), alongside liver cirrhosis (OR, 3.8 [95% CI, 1.9-7.6]; P <.001), primary liver malignancies (OR, 3.8 [95% CI, 1.6-9.3]; P <.001), major hepatectomies (OR, 3.1 [95% CI, 1.7-5.7]; P <.001), and long operating time (OR, 4.2 [95% CI, 2.4-7.2]; P <.001). Patients with long-term diuretic intake were older, had higher body mass indices, and had more comorbidities, including liver cirrhosis. CONCLUSION: Long-term diuretic use is associated with a significantly increased risk of PHLF after open hepatectomy.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Hepatectomy - adverse effects
- Male - administration & dosage
- Female - administration & dosage
- Retrospective Studies - administration & dosage
- Diuretics - adverse effects, administration & dosage
- Middle Aged - administration & dosage
- Aged - administration & dosage
- Risk Factors - administration & dosage
- Liver Failure - etiology, epidemiology
- Postoperative Complications - epidemiology, etiology
- Liver Cirrhosis - administration & dosage
- Incidence - administration & dosage
- Liver Neoplasms - surgery
- Find related publications in this database (Keywords)
- Comedication
- Hepatectomy
- Multimorbidity
- Liver insufficiency
- International Study Group of Liver Surgery