Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Klein, CR; Heine, A; Brossart, P; Karakostas, P; Schäfer, VS.
Anti-MDA5 autoantibodies predict clinical dynamics of dermatomyositis following SARS-CoV-2 mRNA vaccination: a retrospective statistical analysis of case reports.
Rheumatol Int. 2024; 44(10): 2185-2196.
Doi: 10.1007/s00296-024-05683-5
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- Co-Autor*innen der Med Uni Graz
- Heine Annkristin
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- Abstract:
- Since the introduction of mRNA vaccines against SARS-CoV-2, the induction of autoimmunity by mRNA vaccination has been discussed. Several cases of dermatomyositis (DM) associated with mRNA vaccination against SARS-CoV-2 infection have been reported. The question is whether there is a common pathomechanism for the induction of DM by this mRNA vaccination. The aim of this review is to analyse the sample of previously published case reports of DM following COVID-19 mRNA vaccination for common indicators of a possible immune pathomechanism.In this review, we summarised case reports of DM following mRNA vaccination against COVID-19. We considered this case report landscape as a cumulative sample (n = 32) and identified common clinical and molecular parameters in the intersection of case reports and statistically analysed the effect of these parameters on the development of DM.MDA-5 antibodies seem to play a role in the autoantibody signature after mRNA vaccination. MDA-5-positive DM is statistically more strongly associated with mRNA vaccination and interstitial lung disease/rapidly progressive interstitial lung disease (ILD/RP-ILD) than MDA-5-negative DM. MDA-5-positive DM seems not to be associated with an increased risk of malignancy, whereas MDA-5-negative DM is more strongly associated with malignancy.Our findings emphasize the potential role of innate antiviral signalling pathways in connecting DM to mRNA vaccination. MDA-5 autoantibodies appear to be predictive of a severe DM progression following mRNA vaccination. There seems to be an association between MDA-5 autoantibodies and paraneoplastic DM post-vaccination. Further studies are required to uncover the underlying mechanisms of autoimmunity triggered by mRNA vaccination.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Dermatomyositis - immunology
- Interferon-Induced Helicase, IFIH1 - immunology
- Autoantibodies - blood, immunology
- COVID-19 - immunology, prevention & control
- Retrospective Studies - administration & dosage
- Middle Aged - administration & dosage
- Male - administration & dosage
- SARS-CoV-2 - immunology
- Female - administration & dosage
- COVID-19 Vaccines - immunology, adverse effects, administration & dosage
- mRNA Vaccines - immunology
- Aged - administration & dosage
- Adult - administration & dosage
- Find related publications in this database (Keywords)
- Dermatomyositis
- mRNA vaccination
- MDA-5
- Autoimmunity
- COVID-19
- Case report