Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sourij, H; Azhar, K; Aziz, F; Kojzar, H; Sourij, C; Fasching, P; Clodi, M; Ludvik, B; Mader, JK; Resl, M; Rega-Kaun, G; Ress, C; Stechemesser, L; Stingl, H; Tripolt, NJ; Wascher, T; Kaser, S.
Interplay of health-related quality of life and comorbidities in people with type 2 diabetes mellitus treated in primary care settings in Austria: a countrywide cross-sectional study.
BMJ Open. 2025; 15(4):e092951
Doi: 10.1136/bmjopen-2024-092951
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Azhar Kehkishan
- Sourij Harald
- Co-Autor*innen der Med Uni Graz
- Aziz Faisal
- Kojzar Harald
- Mader Julia
- Sourij Caren
- Tripolt Norbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVES: This study assessed the health-related quality of life (HRQoL) and its relationship with clinical factors and comorbidities in people with type 2 diabetes mellitus (T2DM) treated in primary care settings. DESIGN: Cross-sectional study design: This study assessed the HRQoL using a 36-item Short Form Survey (SF-36) tool in eight domains. The HRQoL scores ranged from 0% to 100% for each domain, with higher scores indicating better HRQoL. Linear regression was used to assess the association of HRQoL domain scores with clinical covariates and comorbidities. SETTING: A countrywide study was conducted on individuals with established T2DM (N=635) attending primary healthcare services for various conditions across nine federal states of Austria from 2021 to 2023. PARTICIPANTS: A total of 635 individuals, aged above 50 years and diagnosed with T2DM, were recruited by the attending physician to evaluate their HRQoL in relation to T2DM and its associated comorbidities. RESULTS: The mean SF-36 scores for physical functioning (69±28), role-physical (62±42), mental health (72±20), role-emotional (73±41), social functioning (79±25), bodily pain (67±28) and vitality (55±22) were satisfactory, except for general health (41±10). Age and body mass were inversely associated with physical, mental and social HRQoL (p<0.05). Women had lower mental health (β: -5.44 [95% CI -9.43 to -1.44], p<0.05) than men. Smokers and those with cardiovascular and chronic lung diseases reported worse general, mental and physical health and vitality (p<0.05 each). Depression (p<0.001) and multimorbidity (p<0.05) severely deteriorated all HRQoL domains: physical functioning (Depression:-25.34 [95% CI -33.84 to -16.84], p<0.001); (Multimorbidity: -19.37 [95% CI -26.30 to -12.44], p<0.001), physical role limitations (-22.96 [95% CI -36.65 to -9.27], p<0.001); (-18.53 [95% CI -29.59 to -7.48], p<0.001), social functioning (-24.38 [95% CI -32.41 to -16.35], p<0.001); (-8.86 [95% CI -15.66 to -2.07], p<0.05), emotional well-being (-19.80 [95% CI -26.22 to -13.38], p<0.001); (-9.54 [95% CI -14.95 to -4.13], p<0.001), emotional role limitations (-28.26 [95% CI -41.01 to -15.52], p<0.001); (-8.15 [95% CI -18.78 to 2.49], p=0.133), bodily pains (-23.09 [95% CI -32.21 to -13.97], p<0.001); (-14.52 [95% CI -22.08 to -6.95], p<0.001), fatigue (-16.47 [95% CI -23.40 to -9.55], p<0.001); (-13.71 [95% CI -19.39 to -8.03], p<0.001), general health (-7.09 [95% CI -10.40 to -3.78], p<0.001); (-7.14 [95% CI -9.83 to -4.46], p<0.001). CONCLUSIONS: Our analysis showed that advanced age, obesity, depression, cardiovascular disease, chronic lung diseases and multimorbidity were associated with poor HRQoL of individuals with T2DM at the primary care level. These findings highlight the need for strengthening holistic management in primary care to address the diverse physical, social and emotional needs of individuals with T2DM.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Quality of Life - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Cross-Sectional Studies - administration & dosage
- Diabetes Mellitus, Type 2 - epidemiology, psychology, therapy
- Austria - epidemiology
- Middle Aged - administration & dosage
- Primary Health Care - administration & dosage
- Comorbidity - administration & dosage
- Aged - administration & dosage
- Find related publications in this database (Keywords)
- Diabetes Mellitus, Type 2
- Primary Health Care
- Quality of Life
- Multimorbidity