Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schanda, JE; Huber, S; Behanova, M; Haschka, J; Kraus, DA; Meier, P; Bahrami, A; Zandieh, S; Muschitz, C; Resch, H; Mähr, M; Rötzer, K; Uyanik, G; Zwerina, J; Kocijan, R.
Analysis of bone architecture using fractal-based TX-Analyzer™ in adult patients with osteogenesis imperfecta.
Bone. 2021; 147: 115915
Doi: 10.1016/j.bone.2021.115915
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Kraus Daniel Arian
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- Abstract:
- BACKGROUND: Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by impaired bone quality and quantity. Established imaging techniques have limited reliability in OI. The TX-Analyzer™ is a new, fractal-based software allowing a non-invasive assessment of bone structure based on conventional radiographs. We explored whether the TX-Analyzer™ can discriminate OI patients and healthy controls. Furthermore, we investigated the correlation between TX-Analyzer™ parameters and (i) bone mineral density (BMD) by Dual Energy X-ray Absorptiometry (DXA), (ii) trabecular bone score (TBS), and (iii) bone microstructure by high-resolution peripheral quantitative computed tomography (HR-pQCT). MATERIAL AND METHODS: Data of 29 adult OI patients were retrospectively analyzed. Standard radiographs of the thoracic and lumbar spine were evaluated using the TX-Analyzer™. Bone Structure Value (BSV), Bone Variance Value (BVV), and Bone Entropy Value (BEV) were measured at the vertebral bodies T7 to L5. Data were compared to a healthy, age- and gender-matched control group (n = 58). BMD by DXA, TBS, and trabecular bone microstructure by means of HR-pQCT were correlated to TX-Analyzer™ parameters in OI patients. The accuracy of the TX-Analyzer™ parameters in detecting OI was assessed with area under curve (AUC) analysis of receiver operating characteristic (ROC). RESULTS: BEV of the thoracic and the lumbar spine were significantly lower in OI patients compared to controls (both p < 0.001). BEV of the thoracic spine was significantly correlated to TBS (ρ = 0.427, p = 0.042) as well as trabecular number (Tb.N) at the radius (ρ = 0.603, p = 0.029) and inhomogeneity of the trabecular network (Tb.1/N.SD) at the radius (ρ = -0.610, p = 0.027), when assessed by HR-pQCT. No correlations were found between BEV and BMD by DXA. BEV of the thoracic and the lumbar spine had an AUC of 0.81 (95% confidence interval [CI] 0.67-0.94, p < 0.001) and 0.73 (95% CI 0.56-0.89, p = 0.008), respectively. BSV and BVV did not differ between OI patients and controls. CONCLUSION: The software TX-Analyzer™ is able to discriminate patients with OI from healthy controls. ROC curves of BEV values suggest a suitable clinical applicability. Low to no correlations with conventional methods suggest, that the TX-Analyzer™ may indicate a new and independent examination tool in OI.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorptiometry, Photon - administration & dosage
- Adult - administration & dosage
- Bone Density - administration & dosage
- Fractals - administration & dosage
- Humans - administration & dosage
- Osteogenesis Imperfecta - diagnostic imaging
- Reproducibility of Results - administration & dosage
- Retrospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- Osteogenesis imperfecta
- Bone microstructure
- TX-AnalyzerTM
- Trabecular bone score
- High-resolution peripheral quantitative
- computed tomography