Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Heine, A; Holderried, TAW; Brossart, P.
Immunotherapy in renal cell carcinoma
IMMUNOTHERAPY-UK. 2009; 1(1): 97-107.
Doi: 10.2217/1750743X.1.1.97
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Heine Annkristin
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- Abstract:
- Treatment of metastatic renal cell cancer is still challenging due to its resistance to conventional therapies, such as radiotherapy or chemotherapy. Immunotherapeutic approaches with IL-2 and/or IFN-alpha have become standard regimens in treating metastatic renal cell cancer. Furthermore, molecularly targeted therapies, such as VEGF-pathway inhibition or use of mammalian target of rapamycin inhibitors, have demonstrated promising results and might become even more important in the following years. Finally, vaccination therapies have gained increasing interest and have been tested in multiple clinical trials. There is a vast choice of different application and production types of these vaccines, ranging from dendritic cell-based principals to the application of naked RNA. The development of new immune-enhancing strategies led to the option of interesting, potent combination regimes. This review has a focus on vaccination therapies in renal cell cancer, especially dendritic cell-based principals, and aims to give an overview of this rapidly changing field of investigation.
- Find related publications in this database (Keywords)
- cancer vaccine
- clinical trial
- dendritic cell
- immunotherapy
- renal cell carcinoma