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SHR Neuro Cancer Cardio Lipid Metab Microb

Freystaetter, K; Andreas, M; Bilban, M; Perkmann, T; Kaider, A; Masetti, M; Kocher, A; Wolzt, M; Zuckermann, A.
The recipient's heme oxygenase-1 promoter region polymorphism is associated with cardiac allograft vasculopathy
TRANSPL INT. 2017; 30(5): 510-518. Doi: 10.1111/tri.12935
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Leading authors Med Uni Graz: Andreas Martin
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Abstract:: Heme oxygenase-1 (HO-1) catalyses the degradation of heme to biliverdin, free iron, and carbon monoxide. The promoter region contains a highly polymorphic (GT)(n) repeat, where shorter (GT)(n) repeat sequences are linked to higher transcriptional activity, which was shown to correlate with a cytoprotective effect. Higher HO-1 levels may protect from cardiac allograft vasculopathy. Cardiac allograft recipients transplanted between 1988 and 2012 were analyzed for the HO-1 (GT)(n) repeat polymorphism using PCR and DNA fragment analysis with capillary electrophoresis. A relation to cardiac allograft vasculopathy (CAV) was analyzed using Cox regression including common risk factors for CAV and the occurrence of rejection episodes as explanatory variables. A total of 344 patients were analyzed, of which 127 patients were positive for CAV (36.9%). In our multivariable Cox regression analysis, the short homozygous HO-1 (GT)(n) genotype with <27 repeats (S/S) revealed a higher risk for CAV (P = 0.032). Donor age (P = 0.001) and donor weight (P = 0.005) were significant predictors for CAV. A potential risk for CAV was associated with rejection episodes (P = 0.058) and history of smoking (P = 0.06). The recipient HO-1 (GT)(n) genotype may contribute to CAV development. This finding has to be evaluated in larger series including studies targeting the underlying disease mechanism.
Find related publications in this database (Keywords): cardiac allograft vasculopathy; cardiac transplantation; heme oxygenase-1; polymorphism