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SHR Neuro Cancer Cardio Lipid Metab Microb
Simonato, M; Whisenant, BK; Unbehaun, A; Kempfert, J; Ribeiro, HB; Kornowski, R; Erlebach, M; Bleiziffer, S; Windecker, S; Pilgrim, T; Tomii, D; Guerrero, M; Ahmad, Y; Forrest, JK; Montorfano, M; Ancona, M; Adam, M; Wienemann, H; Finkelstein, A; Villablanca, P; Codner, P; Hildick-Smith, D; Ferrari, E; Petronio, AS; Shamekhi, J; Presbitero, P; Bruschi, G; Rudolph, T; Cerillo, A; Attias, D; Nejjari, M; Abizaid, A; Marchi, MFD; Horlick, E; Wijeysundera, H; Andreas, M; Thukkani, A; Agrifoglio, M; Iadanza, A; Baer, LM; Nanna, MG; Dvir, D.
Clinical and Hemodynamic Outcomes of Balloon-Expandable Mitral Valve-in-Valve Positioning and Asymmetric Deployment The VIVID Registry
JACC-CARDIOVASC INTE. 2023; 16(21): 2615-2627.
Doi: 10.1016/j.jcin.2023.08.047
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PubMed
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- Co-authors Med Uni Graz
- Andreas Martin
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- Abstract:
- BACKGROUND Mitral valve-in-valve (ViV) is associated with suboptimal hemodynamics and rare left ventricular outflow tract (LVOT) obstruction. OBJECTIVES This study aimed to determine whether device position and asymmetry are associated with these outcomes. METHODS Patients undergoing SAPIEN 3 (Edwards Lifesciences) mitral ViV included in the VIVID (Valve-in-Valve In-ternational Data) Registry were studied. Clinical endpoints are reported according to Mitral Valve Academic Research Consortium definitions. Residual mitral valve stenosis was defined as mean gradient $5 mm Hg. Depth of implantation (percentage of transcatheter heart valve [THV] atrial to the bioprosthesis ring) and asymmetry (ratio of 2 measures of THV height) were evaluated. RESULTS A total of 222 patients meeting the criteria for optimal core lab evaluation were studied (age 74 +/- 11.6 years; 61.9% female; STS score = 8.3 +/- 7.1). Mean asymmetry was 6.2% +/- 4.4%. Mean depth of implantation was 19.0% +/- 10.3% atrial. Residual stenosis was common (50%; mean gradient 5.0 +/- 2.6 mm Hg). LVOT obstruction occurred in 7 cases (3.2%). Implantation depth was not a predictor of residual stenosis (OR: 1.19 [95% CI: 0.92-1.55]; P = 0.184), but more atrial implantation was protective against LVOT obstruction (0.7% vs 7.1%; P = 0.009; per 10% atrial, OR: 0.48 [95% CI: 0.24-0.98]; P = 0.044). Asymmetry was found to be an independent predictor of residual stenosis (per 10% increase, OR: 2.30 [95% CI: 1.10-4.82]; P = 0.027). CONCLUSIONS Valve stenosis is common after mitral ViV. Asymmetry was associated with residual stenosis. Depth of implantation on its own was not associated with residual stenosis but was associated with LVOT obstruction. Technical considerations to reduce postdeployment THV asymmetry should be considered. (J Am Coll Cardiol Intv 2023;16:2615-2627) (c) 2023 by the American College of Cardiology Foundation.
- Find related publications in this database (Keywords)
- depth of implantation
- left ventricular outflow tract obstruction
- mitral valve-in-valve
- positioning
- residual stenosis
- SAPIEN 3