Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Andreeva, A; Coti, I; Werner, P; Scherzer, S; Kocher, A; Laufer, G; Andreas, M.
Aortic Valve Replacement in Adult Patients with Decellularized Homografts: A Single-Center Experience
J CLIN MED. 2023; 12(21): 6713
Doi: 10.3390/jcm12216713
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- Co-Autor*innen der Med Uni Graz
- Andreas Martin
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- Abstract:
- Background: decellularized aortic homografts (DAH) represent a promising alternative for aortic valve replacement in young adults due to their low immunogenicity and thrombogenicity. Herein, we report our midterm, single-center experience in adult patients with non-frozen DAH from corlife. Methods: safety, durability, and hemodynamic performance were evaluated according to current guidelines in all consecutive patients who had received a DAH at our center since 03/2016. Results: seventy-three (mean age 47 +/- 11 years, 68.4% (n = 50) male) patients were enrolled. The mean diameter of the implanted DAH was 24 +/- 2 mm. Mean follow-up was 36 +/- 27 months, with a maximum follow-up of 85 months and cumulative follow-up of 215 years. No cases of stenosis were observed, in four (5.5%) cases moderate aortic regurgitation occurred, but no reintervention was required. No cases of early mortality, non-structural dysfunction, reoperation, valve endocarditis, or thrombosis were observed. Freedom from bleeding and thromboembolic events was 100%; freedom from re-intervention was 100%; survival was 98.6% (n = 72). Conclusions: early and mid-term results showed low mortality and 100% freedom from reoperation, thromboembolic events, and bleeding at our center. However, in order for this novel approach to be established as a valid alternative to aortic valve replacement in young patients, long-term data are required.
- Find related publications in this database (Keywords)
- aortic valve disease
- surgical aortic valve replacement
- homografts
- decellularization