Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fischlein, T; Caporali, E; Folliguet, T; Kappert, U; Meuris, B; Shrestha, ML; Roselli, EE; Bonaros, N; Fabre, O; Corbi, P; Troise, G; Andreas, M; Pinaud, F; Pfeiffer, S; Kueri, S; Tan, E; Voisine, P; Girdauskas, E; Rega, F; García-Puente, J; Lorusso, R.
Randomized controlled trial between conventional versus sutureless bioprostheses for aortic valve replacement: Impact of mini and full sternotomy access at 1-year follow-up
INT J CARDIOL. 2022; 368: 56-61. Doi: 10.1016/j.ijcard.2022.08.012
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Andreas Martin
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Abstract:: Background: The present study is a sub-analysis of the multicenter, randomized PERSIST-AVR trial (PERceval Sutureless Implant versus Standard Aortic Valve Replacement) comparing the in-hospital and 1-year results of sutureless versus conventional stented bioprostheses in isolated surgical aortic valve replacement (SAVR) within two different surgical approaches: mini-sternotomy (MS) and full-sternotomy (FS).Methods: A total of 819 patients (per-protocol population) underwent preoperative randomization to sutureless or stented biological valve at 47 centers worldwide. Sub-analysis on isolated SAVR was performed.Results were compared between sutureless and stented within the two different surgical approaches. Results: 285 patients were implanted with Perceval (67% in MS) and 293 with stented valves (65% in MS). Sutureless group showed significantly reduced surgical times both in FS and MS. In-hospital results show no differences between Perceval and stented valves in FS, while a lower incidence of new-onset of atrial fibrillation (3.7% vs 10.8%) with Perceval in MS. After 1-year, use of sutureless valve showed a significant reduction of MACCE (5.2% vs 10.8%), stroke rate (1.0% vs 5.4%), new-onset of atrial fibrillation (4.2% vs 11.4%) and re-hospitalizations (21.8 days vs 47.6 days), compared to stented valves but presented higher rate of pacemaker implantation (11% vs 1.6%).Conclusions: Sutureless bioprosthesis showed significantly reduced procedural times during isolated SAVR in both surgical approaches. Patients with sutureless valves and MS access showed also better 1-year outcome regarding MACCEs, stroke, re-hospitalization and new-onset atrial fibrillation, but presented a higher rate of permanent pacemaker implantation compared to patients with stented bioprosthesis.
Find related publications in this database (Keywords): Aortic valve replacement; Minimally invasive aortic valve replacement; Sutureless aortic valve