Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Brinkmann, M; Müller, T; Köster, M; Schweighofer, J; Danckwardt, M; Giannaccare, G; Marolo, P; Borrelli, E; Reibaldi, M; El-Shabrawi, Y; Toro, MD.
Optical Coherence Tomography Angiography Flow Signal in Non-Treatment-Naïve Patients with Neovascular Age-Related Macular Degeneration Treated with Faricimab.
Medicina (Kaunas). 2025; 61(2):
Doi: 10.3390/medicina61020260
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- Co-authors Med Uni Graz
- El-Shabrawi Yosuf
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- Abstract:
- Background and Objectives: Age-related macular degeneration (AMD) remains a leading cause of legal blindness. Anti-Vascular Endothelial Growth Factor (VEGF) agents are the first-line treatment for neovascular AMD (nAMD). The choroid plays a key role in AMD and is affected by the anti-VEGF treatment. Faricimab, a bispecific antibody additionally targeting angiopoietin 2 (Ang2), was recently approved for nAMD treatment. This study investigates the effect of Faricimab on choroidal flow signal. Materials and Methods: Optical coherence tomography angiography images of 29 nAMD eyes were examined retrospectively. Patients had received treatment with other anti-VEGF agents before Faricimab application. The flow signal in the choroid was measured before, after one and after a series of ≥2 Faricimab injections. Results: The flow signal decreased significantly (p = 0.026) at the choriocapillaris (CC) level after ≥2 injections. The flow signal did not show a significant change in Haller's layer but increased slightly in Sattler's layer (p = 0.034). Conclusions: In conclusion, our results show that the flow signal, especially at the CC level, changed during treatment. Despite the known influence of anti-VEGF treatment on the choroid, auxiliary inhibition of Ang2 might enhance this effect. Due to the retrospective nature, moderate sample size and non-treatment, naïve patients, care must be taken while interpreting our observations. Prospective studies with larger sample sizes and treatment-naïve patients will be needed.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Tomography, Optical Coherence - methods
- Female - administration & dosage
- Male - administration & dosage
- Aged - administration & dosage
- Retrospective Studies - administration & dosage
- Macular Degeneration - drug therapy
- Aged, 80 and over - administration & dosage
- Choroid - blood supply, diagnostic imaging, drug effects
- Angiopoietin-2 - antagonists & inhibitors, blood
- Fluorescein Angiography - methods
- Middle Aged - administration & dosage
- Angiogenesis Inhibitors - therapeutic use
- Intravitreal Injections - administration & dosage
- Find related publications in this database (Keywords)
- Faricimab
- choroid
- OCTA
- anti-VEGF
- angiopoietin 2
- AMD