Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grünig, E; Halank, M; Neurohr, C; Behr, J; Milger-Kneidinger, K; Ronczka, J; Lichtblau, M; Benjamin, N; Lange, TJ; Ulrich, S; Wilkens, H; Grohé, C; Skowasch, D.
[Medication treatment in pulmonary arterial hypertension with comorbidities - Which phenotypes and points to consider].
Pneumologie. 2023; 77(11):901-906
Doi: 10.1055/a-2145-4726
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Milger-Kneidinger Katrin
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- Abstract:
- Within the last decade, the age at diagnosis of patients with pulmonary arterial hypertension has increased, which led to a change of the clinical phenoype being associated with more comorbidities. Cluster analyses of registry data have identified cardiac, cardio-pulmonary and classical phenotypes of pulmonary arterial hypertension.Subgroup analyses of randomised controlled trials and registry data indicate, that in patients with pulmonary arterial hypertension and cardiac comorbidities, especially the left-heart phenotype, a closely supervised combination treatment may be considered. The 4-strata model may be used for monitoring and risk stratification in these patients. Individual treatment decisions should be made in the pulmonary hypertension centre. Factors such as hemodynamics, age, phenotype, number and severity of comorbidities, therapy response, adverse reactions and the wish of the patient should be considered.Prospective, randomized studies to assess the efficacy and safety profile of pulmonary arterial hypertension treatments are desirable. Patients with a mainly pulmonary phenotype (smoking, diffusion capacity of the lung < 45 % and/or lung parenchymal changes) may have less benefit of oral medication.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Pulmonary Arterial Hypertension - administration & dosage
- Prospective Studies - administration & dosage
- Hypertension, Pulmonary - diagnosis, drug therapy
- Comorbidity - administration & dosage
- Phenotype - administration & dosage
- Find related publications in this database (Keywords)
- pulmonary arterial hypertension
- comorbidities
- phenotype
- treatment