Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Milger, K; Korn, S; Buhl, R; Hamelmann, E; Herth, FJ; Gappa, M; Drick, N; Fuge, J; Suhling, H.
Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort.
Respir Med. 2020; 162: 105858
Doi: 10.1016/j.rmed.2019.105858
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Milger-Kneidinger Katrin
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Severe asthma affects less than 5% of asthmatics, but is associated with high costs and increased mortality. The aim of this study was to assess age- and sex-dependent differences in this patient group. METHODS: Retrospective analysis of 1317 children and adults with severe asthma who are included in the German Asthma Net registry. RESULTS: There were more adults than children in the registry and patients' mean age was 52. Apart from children <18 years, there were more women (57%) than men. The age of first diagnosis ranged from 0 to 76 years. 38% of patients had a positive bronchial reversibility after short acting bronchodilators. Quality of life, FEV1 and MEF 25 decreased with older age whereas treatment with oral steroids and monoclonal antibodies increased. An anti-eosinophil treatment was most frequently used in patients aged around 57 years, while an anti-IgE treatment was used in all age-groups including children. There were sex-dependent differences with lower values in men for FEV1, FVC, MEF 25 and DLCO. Yet, women were more frequently unable to work than men due to the disease. CONCLUSION: In patients with severe asthma, clinical characteristics, but also treatments differed between age groups and between the sexes, reflecting different phenotypes of the disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Age Factors - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Anti-Asthmatic Agents - therapeutic use
- Antibodies, Monoclonal - therapeutic use
- Asthma - drug therapy, epidemiology, physiopathology, therapy
- Bronchodilator Agents - therapeutic use
- Child - administration & dosage
- Child, Preschool - administration & dosage
- Cohort Studies - administration & dosage
- Female - administration & dosage
- Germany - epidemiology
- Glucocorticoids - therapeutic use
- Humans - administration & dosage
- Immunoglobulin E - immunology
- Infant - administration & dosage
- Male - administration & dosage
- Maximal Expiratory Flow Rate - administration & dosage
- Middle Aged - administration & dosage
- Omalizumab - therapeutic use
- Quality of Life - administration & dosage
- Retrospective Studies - administration & dosage
- Severity of Illness Index - administration & dosage
- Sex Factors - administration & dosage
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- Severe asthma
- Antibody therapy
- Sex
- Age
- Lung function