Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bal, C; Pohl, W; Milger, K; Skowasch, D; Schulz, C; Gappa, M; Koerner-Rettberg, C; Jandl, M; Schmidt, O; Zehetmayer, S; Taube, C; Hamelmann, E; Buhl, R; Korn, S; Idzko, M, , German, Asthma, Net, (GAN), study, group.
Characterization of Obesity in Severe Asthma in the German Asthma Net.
J Allergy Clin Immunol Pract. 2023; 11(11):3417-3424.e3
Doi: 10.1016/j.jaip.2023.06.049
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Milger-Kneidinger Katrin
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- Abstract:
- BACKGROUND: Asthma is increasingly recognized as heterogeneous, characterized by different endotypes, with obesity not only a distinct phenotype but a risk factor for severe asthma. OBJECTIVE: We sought to understand the associations of obesity with relevant parameters of severe asthma, including asthma control, disease burden, and lung function. METHODS: The German Asthma Net registry is a multicenter international real-life registry capturing long-term follow-up data. This analysis included 2213 patients (52 ± 16 years, 58% female, 29% with obesity [body mass index ≥30 kg/m2], 4.2 ± 4.3 exacerbations/year). The primary analysis assessed relationships between BMI and variables through univariate tests, followed by a multiple regression model. Secondary outcomes regarded clinically relevant variables in relation to weight groups. RESULTS: Patients with obesity were more frequently female, more likely to have depression and gastroesophageal reflux, and suffered from worse asthma control, lower quality of life, reduced static lung volumes, more pronounced hypoxemia, and higher blood neutrophil counts, all statistically significant. Blood eosinophils, exhaled nitric oxide, and total IgE were independent of obesity. In the multiple regression analysis, obesity was significantly associated with more frequent reflux and depression, reduced static lung function values, older age, poor asthma control, and long-acting muscarinic antagonist therapy, and inversely associated with bronchiectasis and nonsmoking status. CONCLUSION: In this large, well-characterized cohort, we identified the association of obesity with a significantly higher disease burden and a similar portfolio of inflammation type 2 markers in patients with and without obesity; therefore, patients with obesity seem similarly eligible for the treatment with biologics targeting these disease endotypes.
- Find related publications in this database (using NLM MeSH Indexing)
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Asthma - administration & dosage
- Eosinophils - administration & dosage
- Gastroesophageal Reflux - administration & dosage
- Obesity - epidemiology
- Quality of Life - administration & dosage
- Risk Factors - administration & dosage
- Middle Aged - administration & dosage
- Aged - administration & dosage
- Adult - administration & dosage
- Find related publications in this database (Keywords)
- Severe asthma
- Obesity
- BMI
- Registry
- Comorbid-ities
- Lung function
- Asthma control
- Exacerbations
- Biomarker