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SHR Neuro Cancer Cardio Lipid Metab Microb

Fandler-Höfler, S; Kaushik, K; Storti, B; Pikija, S; Mallon, D; Ambler, G; Damavandi, PT; Panteleienko, L; Canavero, I; van, Walderveen, MAA; van, Etten, ES; DiFrancesco, JC; Enzinger, C; Gattringer, T; Bersano, A; Wermer, MJH; Banerjee, G; Werring, DJ.
Clinical-radiological presentation and natural history of iatrogenic cerebral amyloid angiopathy.
J Neurol Neurosurg Psychiatry. 2025; Doi: 10.1136/jnnp-2024-335164
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Leading authors Med Uni Graz: Fandler-Höfler Simon
Co-authors Med Uni Graz: Enzinger Christian; Gattringer Thomas; Pikija Slaven
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Abstract:: BACKGROUND: We aimed to describe neuroimaging features, clinical profiles and long-term outcomes in patients with iatrogenic cerebral amyloid angiopathy (iCAA). METHODS: We performed a systematic literature search for case series of iCAA and included individual patients and their longitudinal clinical and neuroimaging data in this pooled cohort study. Patients meeting a modified version of the Queen Square criteria for iCAA were included. Baseline and follow-up MRIs were centrally analysed for markers of CAA using validated rating scales. RESULTS: We included 51 patients (68.6% male, median age at presentation 48 years), 51.0% with probable and 49.0% with possible iCAA. We evaluated 219 MRIs acquired over a median follow-up time of 3.7 years (IQR 1.8-6.4). There were 43 symptomatic intracerebral haemorrhages (ICH) in 24 patients during follow-up, a rate of 16.7 per 100 patient-years.Patients with previous supratentorial brain surgery had an ipsilateral-dominant distribution and spread of haemorrhagic markers on MRI. 14/51 (27.5%) patients had transient inflammatory changes (cortical or parenchymal oedema, sulcal hyperintensities). Haemorrhagic markers progressed during follow-up. In addition to 43 symptomatic ICH, 36 asymptomatic ICH (mostly smaller intragyral haemorrhages) were detected on follow-up scans. Besides numerous lobar microbleeds (median 16 at baseline, 53 at last follow-up), deep microbleeds were present in 19.6% of patients at baseline and 44.4% at follow-up. Severe perivascular spaces in centrum semiovale were common at baseline (64.7%) and follow-up (95.6%). CONCLUSIONS: Patients with iCAA appear to have distinctive MRI characteristics, which might differentiate iCAA from other CAA subtypes and provide new insights into underlying disease mechanisms.
Find related publications in this database (Keywords): AMYLOID; STROKE; PRION; CEREBROVASCULAR DISEASE