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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Saridakis, I; Riomet, M; Belleza, OJV; Coussanes, G; Singer, NK; Kastner, N; Xiao, Y; Smith, E; Tona, V; de, la, Torre, A; Lopes, EF; Sánchez-Murcia, PA; González, L; Sitte, HH; Maulide, N.
PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo-rescence Microscopy.
Angew Chem Int Ed Engl. 2024; 63(19): e202318127
Doi: 10.1002/anie.202318127
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- Co-authors Med Uni Graz
- Sánchez Murcia Pedro Alejandro
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- Abstract:
- The deployment of small-molecule fluorescent agents plays an ever-growing role in medicine and drug development. Herein, we complement the portfolio of powerful fluorophores, reporting the serendipitous discovery and development of a novel class with an imidazo[1,2-a]pyridinium triflate core, which we term PyrAtes. These fluorophores are synthesized in a single step from readily available materials (>60 examples) and display Stokes shifts as large as 240 nm, while also reaching NIR-I emissions at λmax as long as 720 nm. Computational studies allow the development of a platform for the prediction of λmax and λEm. Furthermore, we demonstrate the compatibility of these novel fluorophores with live cell imaging in HEK293 cells, suggesting PyrAtes as potent intracellular markers.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Fluorescent Dyes - chemistry
- HEK293 Cells - administration & dosage
- Microscopy, Fluorescence - administration & dosage
- Salts - chemistry
- Molecular Structure - administration & dosage
- Find related publications in this database (Keywords)
- Fluorescence
- Dyes
- Stokes shift
- Imidazo[1,2-a]pyridinium
- Fluorophore