Medizinische Universität Graz - Research portal
Selected Publication:
Szolar, DH; Saeed, M; Flueckiger, F; Preidler, K; Stiskal, MA; Watzinger, N; Riepl, T; Horina, J.
Pulmonary hypertension. Response of vasoactive peptides to a nonionic contrast medium in patients undergoing pulmonary angiography.
INVEST RADIOL. 1995; 30(9): 511-516.
Doi: 10.1097/00004424-199509000-00001
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- Co-authors Med Uni Graz
- Horina Joerg
- Watzinger Norbert
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- Abstract:
- RATIONALE AND OBJECTIVES. The degree to which pulmonary angiography may contribute to serious complications in patients with pulmonary hypertension has not been clarified and remains a matter of debate. Accordingly, this study was designed (1) to detect the potential release of vasoactive peptides and (2) to investigate the hemodynamic response after administration of a nonionic contrast medium in patients with pulmonary hypertension undergoing pulmonary angiography. Allergy-mediating substances also were measured to monitor for possible anaphylactoid reactions. METHODS. Pulmonary digital subtraction angiography was performed in 20 patients with pulmonary hypertension (mean pulmonary arterial pressure more than 20 mm Hg). Iopromide was administered as a total of 100 mL via a 7F catheter inserted from the right femoral vein. The injected volume and duration of injection (15 to 20 mL/sec) were kept constant. Hemodynamic parameters were continuously monitored, including electrocardiogram, heart rate, phasic and mean pulmonary arterial and peripheral arterial pressures. Blood samples were obtained before and after administration of contrast media to assay for the concentration of the following vasoactive peptides using radioimmunoassay techniques: renin, angiotensin-I-converting enzyme, angiotensin II, aldosterone, atrial natriuretic peptide, antidiuretic hormone, cyclic-guanosine monophosphate, and myoglobin, as well as allergy-mediating substances such as tryptase, eosinophil protein X, and eosinophil cationic protein. RESULTS. Administration of iopromide caused significant increases in atrial natriuretic peptide (from 61.3 +/- 11.8 to 94.0 +/- 16.7) and antidiuretic hormone (from 6.6 +/- 1.9 to 12.3 +/- 3.1), whereas renin significantly decreased (from 3.0 +/- 0.6 to 1.3 +/- 0.5). After administration of contrast media, there were no significant changes in the other measured vasoactive peptides, allergy-mediating substances, and monitored cardiovascular parameters. CONCLUSION. Administration of iopromide for pulmonary angiography in patients with pulmonary hypertension resulted in no appreciable hemodynamic alterations associated with the observed changes in atrial natriuretic peptide, antidiuretic hormone, and renin. No allergy-mediated reactions were observed in these patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aldosterone - blood
- Anaphylaxis - blood
- Angiography, Digital Subtraction - adverse effects
- Angiotensin II - blood
- Atrial Natriuretic Factor - blood
- Blood Pressure - drug effects
- Blood Proteins - analysis
- Chymases - analysis
- Contrast Media - administration and dosage
- Cyclic GMP - blood
- Electrocardiography - drug effects
- Eosinophil Granule Proteins - drug effects
- Eosinophil-Derived Neurotoxin - drug effects
- Female - drug effects
- Heart Rate - drug effects
- Humans - drug effects
- Hypertension, Pulmonary - blood
- Inflammation Mediators - blood
- Iohexol - administration and dosage
- Lung - radiography
- Male - radiography
- Middle Aged - radiography
- Myoglobin - blood
- Peptides - drug effects
- Peptidyl-Dipeptidase A - blood
- Renin - blood
- Ribonucleases - blood
- Serine Endopeptidases - blood
- Tryptases - blood
- Vasopressins - blood
- Find related publications in this database (Keywords)
- Pulmonary Hypertensions
- Contrast Media
- Pulmonary Angiography
- Vasoactive Hormones