Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rashidi, E; Esfandiari, N; Ranjbar, Z; Alvandi, N; Fatahi, Z.
Designing of a pH-activatable carbon dots as a luminescent nanoprobe for recognizing folate receptor-positive cancer cells.
Nanotechnology. 2021; 33(7):
Doi: 10.1088/1361-6528/ac385b
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Esfandiari Neda
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- Abstract:
- During recent years, cancer has been recognized as a well-known disorder all over the world. One of the important factors to tackle this problem better than past decades is early diagnosis that takes into practice by state-of-the-art visual equipment for detection cancer cells. Herein, in this research, we synthesized carbon dots with pH-dependent behavior from a green source by hydrothermal method with high quantum yield and blue fluorescence. Folic acid-conjugated carbon dots by an efficient and optimal conjugation method were set upped which determined cancer cells visually. These synthesized and conjugated nanoparticles entered into the cancer cells more comprehensive than normal cells by receptor-mediated endocytosis and could distinguish cancer cells from normal ones by fluorescence imaging. Ultimately, synthesized nanoparticles in this research can be considered as an efficient fluorescent nanoprobe for cancer pre-diagnosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Fluorescent Dyes - administration & dosage
- Folic Acid - chemistry, metabolism
- Folic Acid Transporters - chemistry, metabolism
- Hep G2 Cells - administration & dosage
- Humans - administration & dosage
- Hydrogen-Ion Concentration - administration & dosage
- Mice - administration & dosage
- Microscopy, Fluorescence - methods
- NIH 3T3 Cells - administration & dosage
- Particle Size - administration & dosage
- Quantum Dots - administration & dosage
- Find related publications in this database (Keywords)
- pH-dependent carbon dots
- cell imaging
- cancer cells detection