Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Alvandi, N; Rajabnejad, M; Taghvaei, Z; Esfandiari, N.
New generation of viral nanoparticles for targeted drug delivery in cancer therapy.
J Drug Target. 2022; 30(2): 151-165.
Doi: 10.1080/1061186X.2021.1949600
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Esfandiari Neda
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- Abstract:
- Nanoscale engineering is one of the novel methods to cure multitudes of diseases, such as types of cancers, neurological disorders, and infectious illnesses. Viruses can play a vital role in nanoscale engineering due to their specific properties like minuscule size, high stability in different body conditions, and large-scale production. Viral-like particles (VLPs) as specific nanoscale scaffolds can encapsulate a wide range of cargos, including nucleic acids, proteins, peptides, and drugs. The Exterior portion of VLPs can be changed by genetical or chemical conjugation as well as targeting ligands or peptides. The aforementioned features of VLPs can be used in several applications, such as drug delivery, bioimaging, tissue engineering, vaccine production, and disease detection. This review article attempts to investigate appearance characteristics, modification strategies, and manufacturing methods of VLPs. Additionally, drug delivery to cancer cells as one of the VLPs applications along with different cellular uptake mechanisms of VLPs by cancer cells are chosen for investigation. This review also tries to gather most of the recent studies of drug delivery to cancer cells by VLPs.
- Find related publications in this database (using NLM MeSH Indexing)
- Drug Delivery Systems - administration & dosage
- Humans - administration & dosage
- Nanoparticles - administration & dosage
- Neoplasms - drug therapy
- Peptides - administration & dosage
- Viruses - administration & dosage
- Find related publications in this database (Keywords)
- VLPs
- viruses
- nanoparticles
- drug delivery
- cancer therapy