Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
PelvEx Collaborative.
Contemporary results from the PelvEx collaborative: improvements in surgical outcomes for locally advanced and recurrent rectal cancer.
Colorectal Dis. 2024; 26(5):926-931
Doi: 10.1111/codi.16948
Web of Science
PubMed
FullText
FullText_MUG
- Study Group Mitglieder der Med Uni Graz:
- Mikalauskas Saulius
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- Abstract:
- AIM: The PelvEx Collaborative collates global data on outcomes following exenterative surgery for locally advanced and locally recurrent rectal cancer (LARC and LRRC, respectively). The aim of this study is to report contemporary data from within the collaborative and benchmark it against previous PelvEx publications. METHOD: Anonymized data from 45 units that performed pelvic exenteration for LARC or LRRC between 2017 and 2021 were reviewed. The primary endpoints were surgical outcomes, including resection margin status, radicality of surgery, rates of reconstruction and associated morbidity and/or mortality. RESULTS: Of 2186 patients who underwent an exenteration for either LARC or LRRC, 1386 (63.4%) had LARC and 800 (36.6%) had LRRC. The proportion of males to females was 1232:954. Median age was 62 years (interquartile range 52-71 years) compared with a median age of 63 in both historical LARC and LRRC cohorts. Compared with the original reported PelvEx data (2004-2014), there has been an increase in negative margin (R0) rates from 79.8% to 84.8% and from 55.4% to 71.7% in the LARC and LRRC cohorts, respectively. Bone resection and flap reconstruction rates have increased accordingly in both cohorts (8.2%-19.6% and 22.6%-32% for LARC and 20.3%-41.9% and 17.4%-32.1% in LRRC, respectively). Despite this, major morbidity has not increased. CONCLUSION: In the modern era, patients undergoing pelvic exenteration for advanced rectal cancer are undergoing more radical surgery and are more likely to achieve a negative resection margin (R0) with no increase in major morbidity.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Rectal Neoplasms - surgery, pathology
- Middle Aged - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Aged - administration & dosage
- Pelvic Exenteration - methods
- Neoplasm Recurrence, Local - surgery
- Margins of Excision - administration & dosage
- Treatment Outcome - administration & dosage
- Benchmarking - administration & dosage
- Plastic Surgery Procedures - methods, statistics & numerical data
- Retrospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- international collaboration
- locally advanced
- rectal cancer
- surgical outcomes
- survival outcomes