Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
van, Heurn, LJ; Derikx, JPM; Hall, N; Aldrink, JH; Bailez, MM; Chirdan, LB; Fumino, S; Hesse, A; Soyer, T; StPeter, S; Twisk, J; Yang, T; van, Heurn, ELW, , SCT-study, consortium.
Malignant transformation and tumour recurrence in sacrococcygeal teratoma: a global, retrospective cohort study.
Int J Surg. 2024; 110(11): 7177-7186.
Doi: 10.1097/JS9.0000000000002045
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Study Group Members Med Uni Graz:
- Till Holger
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- INTRODUCTION: Sacrococcygeal teratoma (SCT) is a rare congenital tumour. The risk of malignancy and recurrence is not well defined. Previous studies are small and report differing conclusions about the timing of surgery and the duration of follow-up. The authors studied the risk of malignant transformation and SCT recurrence after surgery to address these gaps. METHODS: This was a global retrospective cohort study. Data of consecutive SCT patients was obtained from 145 institutes in 62 countries. Malignant transformation, defined as malignancy at initial resection, malignant recurrence or death due to malignancy, and its risk factors were analysed. RESULTS: Of the 3612 included patients, 3407 entered analysis. The risk of malignant transformation of the initial tumour was 3.3, 5.1, 10.1, and 32.9% at age 3 months, 6 months, 1 year, and 2 years, respectively. After 6 years, the censored risk of malignancy (64%) did not further increase. Recurrent SCT was diagnosed in 349 (10.2%) children with 126 (36.1%) malignant recurrences. Risk factors for recurrence were Altman type II [odds ratio (OR): 1.6, 95% confidence interval (CI): 1.2-2.2], Altman type III (OR: 1.6, 95% CI: 1.2-2.3), initial immature histology (OR: 1.9, 95% CI: 1.4-2.6), and initial malignant histology (OR: 4.0, 95% CI: 2.9-5.4). CONCLUSION: The risk of malignancy at initial resection in SCT increases with age reaching a plateau at 6 years of age. Recurrence after resection occurred in 10% of patients and 36% of these were malignant at that time. Altman type II or type III, and immature or malignant histology were associated with recurrence. LEVEL OF EVIDENCE: Level III.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Teratoma - surgery, pathology
- Retrospective Studies - administration & dosage
- Sacrococcygeal Region - pathology
- Neoplasm Recurrence, Local - epidemiology, pathology
- Female - administration & dosage
- Male - administration & dosage
- Infant - administration & dosage
- Cell Transformation, Neoplastic - pathology
- Child, Preschool - administration & dosage
- Risk Factors - administration & dosage
- Cohort Studies - administration & dosage
- Child - administration & dosage
- Infant, Newborn - administration & dosage
- Find related publications in this database (Keywords)
- malignant transformation
- recurrence
- sacrococcygeal teratoma