Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Oettl, K; Reibnegger, G.
Pteridines as inhibitors of xanthine oxidase: structural requirements.
BBA, PROTEIN STRUCT MOL ENZYM. 1999; 1430(2): 387-395.
Doi: 10.1016/S0167-4838(99)00023-0
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- Führende Autor*innen der Med Uni Graz
- Öttl Karl
- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Different pteridine derivatives were investigated for their inhibitory action on xanthine oxidase. From 27 investigated compounds, 13 showed concentration-dependent inhibition of the enzyme. Concentrations necessary for 50% inhibition ranged from <0.1 up to >100 microM. Different types of inhibition were found concerning xanthine and pterin as substrates: competitive, noncompetitive and mixed type. Out of 18 aromatic compounds tested, 12 were inhibitors. Only one out of nine reduced derivatives served as inhibitor. A simple regression model was used to specify the structural requirements for a pteridine to be an inhibitor. The most characteristic features of an inhibitor are aromaticity and no substitution at position 7 of the pteridine ring.
- Find related publications in this database (using NLM MeSH Indexing)
- Dose-Response Relationship, Drug -
- Isomerism -
- Kinetics -
- Neopterin - pharmacology
- Pteridines - pharmacology
- Structure-Activity Relationship - pharmacology
- Xanthine Oxidase - antagonists and inhibitors
- Find related publications in this database (Keywords)
- Pteridine
- Xanthine Oxidase
- Enzyme Inhibition
- Structure