Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Banek, S; Wenzel, M; Lauer, B; Le, QC; Hoeh, B; Koll, F; Cano, Garcia, C; Humke, C; Köllermann, J; Chun, FKH; Kosiba, M; Kluth, LA.
Real-World Evidence of Tumor and Patient Characteristics and Survival with Avelumab Maintenance after Chemotherapy for Advanced and Metastatic Urothelial Carcinoma.
Urol Int. 2024; 108(4): 285-291.
Doi: 10.1159/000538237
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Koll Florestan Johannes
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- INTRODUCTION: Despite the prospective randomized controlled JAVELIN Bladder 100 trial, no real-world evidence exists regarding tumor characteristics, adverse events (AEs), and survival of avelumab maintenance (AVM)-treated patients with partial/complete response or stable disease after previous platinum-based chemotherapy for advanced/metastatic urothelial carcinoma (mUC). METHODS: We relied on our institutional database to identify mUC patients who received AVM between January, 2021 and December, 2023. The main outcomes consisted of overall survival (OS) and progression-free survival (PFS) and were computed by Kaplan-Meier estimates. Stratification was performed according to programmed death ligand 1 (PD-L1) status. RESULTS: Overall, 24 AVM patients were identified at a median age of 71 (interquartile range [IQR]: 67-76) years, of which 67% were males. Of these, 63%, 21%, and 17% received AVM therapy for bladder cancer and upper tract urothelial carcinoma or both, respectively. PD-L1 status was positive in 45% of patients. During AVM treatment, AEs were observed in 33% of patients; however, they were limited to ≤2 grade AEs. At a median follow-up of eight (IQR 4-20) months, 71% of patients had progressed under AVM with median PFS of 6.2 months (confidence interval [CI]: 3.2-18.2). Median OS was 13.4 (CI: 6.9 - not reached [NR]) months. One-year OS after AVM was 52%. In PD-L1-positive patients, median PFS and OS were 6.4 (CI: 2.7 - NR) months and 13.4 (CI: 7.7 months - NR), respectively. CONCLUSION: AVM is associated with moderate AE rates. Despite similarities in baseline characteristics compared to trial-selected JAVELIN Bladder 100 mUC patients, AVM resulted in longer/similar PFS but significantly shorter OS in real-world setting.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Male - administration & dosage
- Antibodies, Monoclonal, Humanized - therapeutic use, adverse effects
- Female - administration & dosage
- Aged - administration & dosage
- Carcinoma, Transitional Cell - drug therapy, mortality, secondary
- Antineoplastic Agents, Immunological - therapeutic use, adverse effects
- Urinary Bladder Neoplasms - drug therapy, mortality, pathology
- Survival Rate - administration & dosage
- Maintenance Chemotherapy - administration & dosage
- Retrospective Studies - administration & dosage
- Neoplasm Metastasis - administration & dosage
- Treatment Outcome - administration & dosage
- Urologic Neoplasms - drug therapy, mortality, pathology
- Middle Aged - administration & dosage
- Find related publications in this database (Keywords)
- Avelumab
- Maintenance
- Metastatic urothelial carcinoma
- UTUC