Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Banek, S; Hoeh, B; Cano, Garcia, C; Koll, F; Köllermann, J; Chun, FKH; Mandel, P; Kluth, LA; Wenzel, M.
Metastatic Squamous Cell Carcinoma of the Urinary Bladder: Urgent Call for New Therapies.
Urol Int. 2024; 108(1): 1-8.
Doi: 10.1159/000534858
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- Co-authors Med Uni Graz
- Koll Florestan Johannes
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- Abstract:
- BACKGROUND: Squamous cell carcinoma (SCC) of the urinary bladder is the most common non-urothelial variant histology. Currently, upfront radical cystectomy is the gold standard for non-metastatic SCC of the bladder. However, several studies have shown that SCC of the bladder is associated with higher aggressiveness and worse survival outcomes, such as progression-free and cancer-specific survival, relative to the urothelial histological subtype. Moreover, metastatic SCC seems to poorly respond to systemic treatments and/or radiotherapy. SUMMARY: This review summarizes the current knowledge and medical evidence regarding local and systematic treatment of mSCC of the bladder, including a case series of four initially locally advanced and later metastatic SCC patients of our tertiary care hospital. KEY MESSAGES: Despite being the second most common variant histology of bladder cancer, current therapies for SCC do not provide satisfactory therapeutic responses.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Urinary Bladder - pathology
- Retrospective Studies - administration & dosage
- Urinary Bladder Neoplasms - pathology
- Cystectomy - administration & dosage
- Carcinoma, Squamous Cell - therapy
- Carcinoma, Transitional Cell - surgery
- Find related publications in this database (Keywords)
- Squamous cell carcinoma
- Bladder cancer
- Metastatic stages
- Chemotherapy