Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Falchetto, L; Bender, B; Erhard, I; Zeiner, KN; Stratmann, JA; Koll, FJ; Wagner, S; Reiser, M; Gasimli, K; Stehle, A; Voss, M; Ballo, O; Vehreschild, JJ; Maier, D.
Concepts of lines of therapy in cancer treatment: findings from an expert interview-based study.
BMC Res Notes. 2024; 17(1): 137
Doi: 10.1186/s13104-024-06789-6
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- Co-Autor*innen der Med Uni Graz
- Koll Florestan Johannes
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- Abstract:
- OBJECTIVE: The concept of lines of therapy (LOT) in cancer treatment is often considered for decision making in tumor boards and clinical management, but lacks a common definition across medical specialties. The complexity and heterogeneity of malignancies and treatment modalities contribute to an inconsistent understanding of LOT among physicians. This study assesses the heterogeneity of understandings of the LOT concept, its major dimensions, and criteria from the perspective of physicians of different specialties with an oncological focus in Germany. Semi-structured expert interviews with nine physicians were conducted and evaluated using qualitative content analysis. RESULTS: Most interviewees agreed that there is no single definition for LOT and found it difficult to explicate their understanding. A majority of experts stated that they had already encountered misunderstandings with colleagues regarding LOT and that they had problems with deciphering LOT from the medical records of their patients. Disagreement emerged about the roles of the following within the LOT concept: maintenance therapy, treatment intention, different therapy modalities, changing pharmaceutical agents, and therapy breaks. Respondents predominantly considered the same criteria as decisive for the definition of LOT as for a change in LOT (e.g., the occurrence of a progression event or tumor recurrence).
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Neoplasms - therapy, drug therapy
- Male - administration & dosage
- Female - administration & dosage
- Interviews as Topic - administration & dosage
- Germany - administration & dosage
- Middle Aged - administration & dosage
- Qualitative Research - administration & dosage
- Adult - administration & dosage
- Physicians - psychology
- Find related publications in this database (Keywords)
- Lines of therapy
- cancer treatment
- Therapy planning
- Expert interview