Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lichtenegger, E; Koll, F; Haas, H; Mantwill, K; Janssen, KP; Laschinger, M; Gschwend, J; Steiger, K; Black, PC; Moskalev, I; Nawroth, R; Holm, PS.
The Oncolytic Adenovirus XVir-N-31 as a Novel Therapy in Muscle-Invasive Bladder Cancer.
Hum Gene Ther. 2019; 30(1): 44-56.
Doi: 10.1089/hum.2018.026
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Koll Florestan Johannes
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- Abstract:
- Muscle-invasive bladder cancer represents approximately 25% of diagnosed bladder cancer cases and carries a significant risk of death. Oncolytic viruses are novel antitumor agents with the ability to selectively replicate and lyse tumor cells while sparing healthy tissue. We explored the efficiency of the oncolytic YB-1-selective adenovirus XVir-N-31 in vitro and in an orthotopic mouse model for bladder cancer by intramural injection under ultrasound guidance. We demonstrated that XVir-N-31 replicated in bladder cancer cells and induced a stronger immunogenic cell death than wild-type adenovirus by facilitating enhanced release of HMGB1 and exosomal Hsp70. The intratumoral delivery of XVir-N-31 by ultrasound guidance delayed tumor growth in an immunodeficient model, demonstrating the feasibility of this approach to deliver oncolytic viruses directly into the tumor.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoviridae - genetics
- Animals - administration & dosage
- Cell Death - genetics
- Cell Line, Tumor - administration & dosage
- Disease Models, Animal - administration & dosage
- Flow Cytometry - administration & dosage
- Fluorescent Antibody Technique - administration & dosage
- Gene Expression - administration & dosage
- Gene Transfer Techniques - administration & dosage
- Genetic Therapy - methods
- Genetic Vectors - administration & dosage, genetics
- Humans - administration & dosage
- Mice - administration & dosage
- Oncolytic Virotherapy - methods
- Oncolytic Viruses - genetics
- Transgenes - administration & dosage
- Tumor Burden - administration & dosage
- Urinary Bladder Neoplasms - genetics, metabolism, pathology, therapy
- Xenograft Model Antitumor Assays - administration & dosage
- Y-Box-Binding Protein 1 - genetics, metabolism
- Find related publications in this database (Keywords)
- adenovirus
- ultrasound guided
- bladder cancer
- oncolytic
- virotherapy
- YB-1
- MIBC