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Meys, R; Franssen, FME; Van, 't, Hul, AJ; Bakke, PS; Caruso, M; Dahlén, B; Fowler, SJ; Geiser, T; Howarth, PH; Horváth, I; Krug, N; Behndig, AF; Singer, F; Musial, J; Shaw, DE; Montuschi, P; Zee, AHM; Sterk, PJ; Roberts, G; Kermani, NZ; Incalzi, RA; Louis, R; Andersson, LI; Wagers, SS; Dahlén, SE; Chung, KF; Adcock, IM; Spruit, MA, , U-BIOPRED, Study, Group.
Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED.
Health Qual Life Outcomes. 2024; 22(1): 109 Doi: 10.1186/s12955-024-02321-3 [OPEN ACCESS]
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Co-authors Med Uni Graz: Singer Florian
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Abstract:: RATIONALE: Knowledge about the clinical importance of patient-reported outcome measures (PROMs) in severe asthma is limited. OBJECTIVES: To assess whether and to what extent asthma exacerbations affect changes in PROMS over time and asthma-specific PROMs can predict exacerbations in adult patients with severe asthma in usual care. METHODS: Data of 421 patients with severe asthma (62% female; mean age 51.9 ± 13.4 years; mean FEV₁ 67.5 ± 21.3%pred) from the U-BIOPRED cohort were analyzed. The included PROMs were: Asthma Control Questionnaire (ACQ5); Asthma Quality of Life Questionnaire (AQLQ); Hospital Anxiety and Depression scale (HADS); Epworth Sleepiness Scale (ESS); Medication Adherence Report Scale (MARS); Sino-Nasal Outcomes Test (SNOT20). Participants were assessed at baseline and after 12-18 months of usual care. RESULTS: PROMs showed very weak to weak correlations with clinical characteristics such as age, body mass index, FEV₁, FeNO and eosinophilic cell count. Patients presenting no exacerbations during follow-up showed a statistically significant improvement in all PROMs (except for MARS), whereas individuals experiencing > 2 exacerbations showed a deterioration. Baseline ACQ5 was a predictor of exacerbations with an AUC of 0.590 (95%CI 0.514-0.666). CONCLUSIONS: The association of PROMs with clinical measures was poor in severe asthmatics. Moreover, PROMs were prone to changes in usual care, with exacerbations playing a key role. PROMs need to be systematically evaluated in severe asthma to improve clinical care based on specific patient's needs.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Asthma - drug therapy, therapy, psychology, physiopathology; Female - administration & dosage; Male - administration & dosage; Patient Reported Outcome Measures - administration & dosage; Middle Aged - administration & dosage; Adult - administration & dosage; Quality of Life - administration & dosage; Surveys and Questionnaires - administration & dosage; Severity of Illness Index - administration & dosage; Clinical Relevance - administration & dosage
Find related publications in this database (Keywords): Obstructive pulmonary diseases; Patient outcome assessment; Health status