Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hirsch, IB; Khakpour, D; Joseph, J; Shinohara, MM; Wang, RK; Klueh, U; Kreutzner, D; Riveline, JP; Jacquemier, P; Maier, L; Longaker, MT; Parkin, CG; Pieber, T; Kalus, A.
The DERMIS Study: Methodologies, Results, and Implications for the Future.
J Diabetes Sci Technol. 2024; 19322968241298005
Doi: 10.1177/19322968241298005
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- Co-authors Med Uni Graz
- Pieber Thomas
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- Abstract:
- Ongoing innovation in diabetes technologies has led to the development of advanced tools such as automated insulin delivery (AID) systems that adjust insulin delivery in response to current and predicted glucose levels, residual insulin action, and other inputs (eg, meal and exercise announcements). However, infusion sets continue to be the "Achilles heel" of accurate and precise insulin delivery and continued device use. A recent study by Kalus et al (DERMIS Study) revealed higher vessel density and signals of inflammation by optical coherence tomography (OCT), in addition to increased inflammation, fat necrosis, fibrosis, and eosinophilic infiltration by histopathology. Although the study provided a comprehensive description of what was happening, the results raise important questions that require additional research. On February 29, 2024, the Leona M. and Harry B. Helmsley Charitable Trust sponsored a conference to begin addressing these issues. This article summarizes the DERMIS study findings and testing methodologies discussed at the conference and proposes the next steps for developing insulin infusion sets that reduce the variability in insulin delivery and extend wear.
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