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SHR Neuro Cancer Cardio Lipid Metab Microb

Moik, F; Ay, C.
Treatment of VTE in the thrombocytopenic cancer patient.
Hematology Am Soc Hematol Educ Program. 2024; 2024(1): 259-269. Doi: 10.1182/hematology.2024000551 (- Case Report) [OPEN ACCESS]
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Leading authors Med Uni Graz: Moik Florian
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Abstract:: Thrombocytopenia is a frequent complication in patients with cancer, mostly due to the myelosuppressive effects of antineoplastic therapies. The risk of venous thromboembolism (VTE) in patients with cancer is increased despite low platelet counts. The management of cancer-associated VTE in patients with thrombocytopenia is challenging, as the risk of both recurrent VTE and bleeding complications is high. Moreover, the time-dependent nature of thrombocytopenia over the course of antineoplastic therapies further complicates the management of patients in clinical practice. In the absence of evidence from high-quality studies, the management of anticoagulation therapy for VTE must be personalized, balancing the individual risk of VTE progression and recurrence against the risk of hemorrhage. In the present case-based review, we highlight the clinical challenges that arise upon managing cancer-associated VTE in the setting of present or anticipated thrombocytopenia, summarize the available evidence, and provide a comparative overview of available guidelines.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Thrombocytopenia - therapy, complications, drug therapy; Venous Thromboembolism - etiology, drug therapy; Neoplasms - complications; Male - administration & dosage; Female - administration & dosage; Hemorrhage - etiology, therapy; Anticoagulants - therapeutic use; Middle Aged - administration & dosage; Aged - administration & dosage; Antineoplastic Agents - therapeutic use, adverse effects