Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Peris, K; Cerroni, L; Chimenti, S; Soyer, HP; Kerl, H; Höfler, H.
Proto-oncogene expression in dermal naevi and melanomas.
Arch Dermatol Res. 1991; 283(8):500-505
Doi: 10.1007/BF00371922
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- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Kerl Helmut
- Soyer Hans Peter
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- Abstract:
- Overexpression of proto-oncogenes (c-onc) may be involved in the initiation and progression of human neoplasia. We investigated the mRNA expression of the proto-oncogenes c-myc, c-fos, c-neu (erb B-2) and Ha-ras in 12 cutaneous melanocytic lesions (four dermal naevi, seven melanomas; one cutaneous metastatis of melanoma) and in normal skin (five cases) by Northern blot analysis; mRNA expression levels were quantified by densitometry of the specific bands. The expression of c-myc mRNA was higher in naevi than in melanomas, whereas c-fos mRNA expression was significantly higher in melanomas than in naevi. No significant differences were detected in the c-neu and Ha-ras mRNA levels in naevi and melanomas. The expression of c-neu mRNA was higher in normal skin than in the melanocytic lesions examined. Our results suggest that enhanced c-myc and c-fos expression may play an important role in the growth of melanocytic naevi and melanomas. The overexpression of c-fos may be involved in the progression of a particular subset of melanoma. Activation of Ha-ras and the c-neu gene, as determined by mRNA overexpression, does not seem to play a significant role in the progression of cutaneous pigmented lesions. Expression of c-neu may have an important function in the proliferation and/or differentiation of normal cells of the epidermis.
- Find related publications in this database (using NLM MeSH Indexing)
- Genes, fos -
- Genes, myc -
- Genes, ras -
- Humans -
- Melanoma - genetics
- Nevus - genetics
- Proto-Oncogene Proteins - genetics
- Proto-Oncogenes -
- RNA, Messenger - analysis
- Receptor, erbB-2 -
- Skin Neoplasms - genetics
- Find related publications in this database (Keywords)
- Nevi
- Melanomas
- Oncogenes