Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Abramowicz, M; Trampuz, A; Kühn, KD.
Tigecycline Containing Polymethylmethacrylate Cement Against MRSA, VRE, and ESBL-In Vitro Mechanical and Microbiological Investigations.
Antibiotics (Basel). 2024; 13(11):
Doi: 10.3390/antibiotics13111102
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- Führende Autor*innen der Med Uni Graz
- Kühn Klaus-Dieter
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- Abstract:
- BACKGROUND: The use of antibiotic-loaded bone cements (ALBCs) in arthroplasty has been well established for the prevention and treatment of infections. Tigecycline (Tig), a broad-spectrum antibiotic, has shown efficacy against various pathogens, including vancomycin-resistant strains. METHOD: ISO and DIN mechanical and microbiological inhibition zone tests were performed on PMMA cement with manually added Tigecycline. RESULTS: Manually adding 0.5 and 1.0 g Tigecycline to PMMA always meets the mechanical requirements of ISO and DIN standards. Mixtures containing 0.5 g were microbiologically effective for up to 7 days and those containing 1.0 g were effective for 28-42 days. CONCLUSION: In revision surgery, manually adding Tigecycline in doses of 0.5-1 g to 40 g of PMMA is effective against MRSA, VRE, and ESBL without negatively affecting the cement's properties.
- Find related publications in this database (Keywords)
- tigecycline
- PMMA
- mechanical properties
- efficacy
- MRSA
- VRE
- ESBL