Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hau, HM; Schmelzle, M; Benzing, C; Ascherl, R; Tautenhahn, HM; Gäbelein, G; Eichfeld, U; Bartels, M.
Pulmonary metastasectomy for metastasized hepatocellular carcinoma after liver resection and liver transplantation: a single center experience.
Z Gastroenterol. 2016; 54(1): 31-9.
Doi: 10.1055/s-0041-104025
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hau Hans-Michael
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- Abstract:
- BACKGROUND: The role of surgery in the treatment of metastasized hepatocellular carcinoma (HCC) remains uncertain. We here report our single centre experience with pulmonary metastasectomy (PM) for metachronous HCC metastases to the lung following curative liver resection (LR) and liver transplantation (LT), respectively. METHODS: Of 270 patients with HCC being treated by LR or LT at the University Hospital of Leipzig between January 1996 and July 2014, PM was performed in the follow up of 10 patients because of metachronous pulmonary HCC metastases. We retrospectively analyzed demographic and clinicopathological factors as well as the outcome after primary and secondary tumor treatment in these patients. RESULTS: Following LR/LT and metastasectomy, respectively, mean overall survival was 4.58 ± 0.84 years and 2.4 ± 0.69 years. Postoperative morbidity after primary and secondary tumor treatment was 30 % and 20 %, respectively. Perioperative 30-day mortality was 0 %. Univariate analysis suggest tumor grading (p < 0.05), and a disease free-intervall > 1 year (p = 0.02) as significant prognostic parameters for survival in our collective. CONCLUSION: PM can be performed safely with a reasonable morbidity even in immunosuppressed patients after LT. Further studies are needed to evaluate whether PM can increase long-term survival in selected patients with resectable metastases and represents an alternative or additive treatment modality to the protein kinase inhibitor sorafenib.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Hepatocellular - mortality, secondary, surgery
- Female - administration & dosage
- Germany - epidemiology
- Hepatectomy - mortality
- Humans - administration & dosage
- Liver Transplantation - mortality
- Lung Neoplasms - mortality, secondary, surgery
- Male - administration & dosage
- Metastasectomy - methods, mortality
- Middle Aged - administration & dosage
- Prevalence - administration & dosage
- Retrospective Studies - administration & dosage
- Risk Factors - administration & dosage
- Survival Rate - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- pulmonaler Metastasen
- Metastasektomie
- hepatozellulares Karzinom
- pulmonary metastases
- metastasectomy
- hepatocellular carcinoma