Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wiltberger, G; Muhl, B; Benzing, C; Hau, HM; Bartels, M; Krenzien, F.
Pancreaticoduodenectomy in the Elderly Patient: Age-Adapted Risk Assessment.
Dig Surg. 2017; 34(1): 43-51.
Doi: 10.1159/000448059
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Hau Hans-Michael
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- Abstract:
- BACKGROUND: Older patients are increasingly faced with pancreatic surgery because of shifting demographics. The differential effects of aging on surgical outcomes remain vague, while the elderly patient is often neglected in clinical trials. METHODS: Medical records of 370 patients who underwent pancreaticoduodenectomy were analyzed. Patients were then subdivided into 3 groups according to age and comorbidities. RESULTS: Overall mortality was 5% and did not significantly differ between age-matched groups. Increasing age was linked to a higher prevalence of diabetes mellitus (p < 0.001) and preoperative cardiovascular comorbidities (p < 0.001). Independent risk factors for major complications were age over 70 years (p = 0.018; OR 2.3), elevated body mass index (p = 0.004; OR 0.2) and cardiovascular comorbidities (p = 0.022; OR = 2.6). Patients who were older (>70 years), obese and had cardiovascular disease had an increased risk of major complications when compared with the younger study population (p = 0.010). CONCLUSIONS: Pancreatic surgery in elderly patients showed similar mortality rates as in younger patients. Nevertheless, a careful risk assessment is particularly important because older patients who are considered to be high risk suffer more frequently from major surgical complications compared with young patients that have similar risk profiles.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Age Factors - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Body Mass Index - administration & dosage
- Carcinoma, Pancreatic Ductal - epidemiology, mortality, surgery
- Cardiovascular Diseases - epidemiology
- Comorbidity - administration & dosage
- Diabetes Mellitus - epidemiology
- Disease-Free Survival - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Obesity - epidemiology
- Pancreatic Neoplasms - epidemiology, mortality, surgery
- Pancreaticoduodenectomy - adverse effects, mortality
- Prevalence - administration & dosage
- Risk Assessment - methods
- Risk Factors - administration & dosage
- Survival Rate - administration & dosage
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- Elderly
- Major complications
- Pancreaticoduodenectomy