Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Benzing, C; Krezdorn, N; Förster, J; Hinz, A; Atanasov, G; Wiltberger, G; Morgül, MH; Lange, UG; Schmelzle, M; Hau, HM; Bartels, M.
Impact of different immunosuppressive regimens on the health-related quality of life following orthotopic liver transplantation.
Clin Transplant. 2015; 29(12): 1081-9.
Doi: 10.1111/ctr.12631
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Hau Hans-Michael
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- Abstract:
- BACKGROUND: The influence of immunosuppression on the recipients' quality of life (QoL) is of major importance after OLT and has not yet been evaluated. METHODS: The impact of different immunosuppression regimens after OLT was evaluated in 275 patients using the Short Form 36 (SF-36) survey. The following immunosuppressive strategies were compared: (a) CNI, (b) mTOR inhibitors, and (c) mTOR combined with CNI. All regimens were prescribed alone (mono) or in combination (+) with prednisolone and/or mycophenolate mofetil (MMF). RESULTS: Highest scores were evident in patients in the mTOR+ group. There were significantly higher values for general health perceptions (GH, p = 0.049), vitality (VIT, p = 0.020), and physical component summary (PCS, p = 0.041) when compared to CNImono and for GH (p = 0.042) and VIT (p = 0.043), when compared to mTORmono. Early conversion to mTOR inhibitors (
two months after OLT), with a statistically significant improvement for the dimension role-emotional (RE, p = 0.027). DISCUSSION: mTOR inhibitor-based regimens appear to have beneficial effects on QoL after OLT, especially after an early conversion. - Find related publications in this database (using NLM MeSH Indexing)
- Drug Therapy, Combination - administration & dosage
- Female - administration & dosage
- Follow-Up Studies - administration & dosage
- Graft Rejection - epidemiology, prevention & control
- Graft Survival - administration & dosage
- Humans - administration & dosage
- Immunosuppression Therapy - administration & dosage
- Immunosuppressive Agents - therapeutic use
- Incidence - administration & dosage
- Liver Diseases - surgery
- Liver Transplantation - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Postoperative Complications - administration & dosage
- Prognosis - administration & dosage
- Quality of Life - administration & dosage
- Risk Factors - administration & dosage
- Find related publications in this database (Keywords)
- early conversion
- immunosuppression
- liver transplantation
- Quality of Life
- SF-36