Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Atanasov, G; Dino, K; Schierle, K; Dietel, C; Aust, G; Pratschke, J; Seehofer, D; Schmelzle, M; Hau, HM.
Angiogenic inflammation and formation of necrosis in the tumor microenvironment influence patient survival after radical surgery for de novo hepatocellular carcinoma in non-cirrhosis.
World J Surg Oncol. 2019; 17(1): 217
Doi: 10.1186/s12957-019-1756-8
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- Co-Autor*innen der Med Uni Graz
- Hau Hans-Michael
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- Abstract:
- BACKGROUND: Tumor escape mechanisms mediated in the tumor microenvironment can significantly reduce the capacity of the anti-tumor function of the immune system. TIE2-expressing monocytes (TEMs), related angiopoietins, and tumor necrosis are considered to have a key role in this process. We aimed to investigate the abundance and clinical significance of these biomarkers in hepatocellular carcinoma (HCC). METHODS: In this retrospective study, 58 HCC patients received surgery with a curative intent. The abundance of TEMs, angiopoietin-1 and -2 were detected in tumor specimens of the HCC patients (n = 58), and together with the occurrence of histologic tumor necrosis, were associated with established clinicopathological characteristics and survival. RESULTS: Patients with HCC characterized by necrosis and TEMs revealed reduced both overall survival and recurrence-free survival (all p < 0.05). Angiopoietins and TEMs were associated with metastatic and recurrent HCC. Furthermore, the formation of histologic tumor necrosis was associated with advanced tumor stage and density of TEMs (all p < 0.05). CONCLUSIONS: Histologic tumor necrosis, TEMs, and related angiopoietins were associated with multiple HCC parameters and patient survival. The tumor necrosis-TEM-angiopoietin axis may offer a novel diagnostic modality to predict patient outcome after surgery for HCC.
- Find related publications in this database (using NLM MeSH Indexing)
- Angiopoietin-1 - metabolism
- Angiopoietin-2 - metabolism
- Biomarkers, Tumor - metabolism
- Carcinoma, Hepatocellular - immunology, mortality, pathology, surgery
- Female - administration & dosage
- Humans - administration & dosage
- Inflammation - immunology, metabolism, pathology
- Liver Neoplasms - immunology, mortality, pathology, surgery
- Male - administration & dosage
- Middle Aged - administration & dosage
- Monocytes - immunology, metabolism, pathology
- Necrosis - administration & dosage
- Neoplasm Grading - administration & dosage
- Neovascularization, Pathologic - immunology, pathology
- Prognosis - administration & dosage
- Receptor, TIE-2 - metabolism
- Retrospective Studies - administration & dosage
- Tumor Escape - administration & dosage
- Tumor Microenvironment - administration & dosage
- Find related publications in this database (Keywords)
- Hepatocellular carcinoma
- Tumor-infiltrating macrophages
- TIE2-expressing monocytes
- Tumor necrosis
- Angiopoietins
- Angiogenesis
- Prognosis