Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wiltberger, G; Krenzien, F; Atanasov, G; Hau, HM; Schmelzle, M; Bartels, M; Benzing, C.
Pancreaticoduodenectomy for periampullary cancer: does the tumour entity influence perioperative morbidity and long-term outcome?
Acta Chir Belg. 2018; 118(6): 341-347.
Doi: 10.1080/00015458.2017.1385894
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Hau Hans-Michael
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Malignant tumours of the periampullary region include ductal adenocarcinoma of the pancreas (Pan-Ca), distal bile duct cancer (DBDC) and adenocarcinoma of the ampulla (Amp-Ca). The present retrospective clinical study was designed to evaluate the influence of tumour entity on postoperative complications and identify risk factors predicting survival and morbidity. METHODS: We retrospectively analysed data from all patients who underwent pancreatic resection for periampullary cancer with curative intent (R0 or R1). Demographic data, risk factors, perioperative complications and survival rates for the different subtypes were assessed. RESULTS: A total of 225 patients with periampullary cancer were identified: 124 (55.1%) had Pan-Ca, 55 (24.4%) had DBDC and 46 had (20.4%) Amp-Ca. Sixty-nine patients (30.7%) had major complications (grade IIIb-V). Patients with DBDC had significantly more grade C pancreatic fistulas. Univariate analysis revealed male gender, BMI >30, R1-status, and low-grade tumour differentiation as risk factors for major complications. Overall in-hospital-mortality was 6.7%. CONCLUSIONS: Further research will be needed to implement more individualized therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - mortality, pathology, surgery
- Adult - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Ampulla of Vater - pathology, surgery
- Cohort Studies - administration & dosage
- Common Bile Duct Neoplasms - mortality, pathology, surgery
- Disease-Free Survival - administration & dosage
- Female - administration & dosage
- Follow-Up Studies - administration & dosage
- Germany - administration & dosage
- Humans - administration & dosage
- Kaplan-Meier Estimate - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Pancreatic Neoplasms - mortality, pathology, surgery
- Pancreaticoduodenectomy - adverse effects, methods, mortality
- Perioperative Care - methods
- Postoperative Complications - mortality, physiopathology
- Retrospective Studies - administration & dosage
- Risk Assessment - administration & dosage
- Statistics, Nonparametric - administration & dosage
- Survival Analysis - administration & dosage
- Time Factors - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- Periampullary cancer
- complications
- pancreaticoduodenectomy