Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stauber, RE; Heinemann, A.
Propranolol stereoselectively inhibits alpha-adrenoceptor-mediated vasoconstriction in mesenteric arterial beds of rats.
J AUTONOM PHARMACOL. 1996; 16(3): 125-129.
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Stauber Rudolf
- Co-Autor*innen der Med Uni Graz
- Heinemann Akos
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- Abstract:
- 1. The optical isomers of propranolol were compared for their effects on pressor responses to adrenergic and non-adrenergic vasoconstrictors in mesenteric arterial beds of rats. 2. R(+)-propranolol (10(-7)-10(-5) M) had no effect on vessel preparations stimulated with noradrenaline, methoxamine, or arginine-vasopressin. 3. S(-)-propranolol 10(-7) M did not alter pressor responses to noradrenaline. However, S(-)-propranolol 10(-6) and 10(-5) M inhibited vasoconstriction induced by noradrenaline. This effect was similar in the presence of indomethacin 3 x 10(-6) M. 4. S(-)-propranolol 10(-5) M also inhibited vasoconstriction induced by methoxamine, shifting the dose-response curves to the right, but did not affect pressor responses to arginine-vasopressin. 5. Schild analysis for equilibrium vasoconstrictor responses to methoxamine indicated stereoselective competitive alpha-adrenoceptor antagonism by propranolol. 6. These data suggest selective inhibition of alpha-adrenoceptor-mediated vasoconstriction by S(-)-propranolol at higher concentrations by competitive alpha-adrenoceptor antagonism.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic alpha-Agonists - pharmacology
- Adrenergic beta-Antagonists - pharmacology
- Analysis of Variance - pharmacology
- Animals - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Male - pharmacology
- Mesenteric Arteries - pharmacology
- Methoxamine - antagonists and inhibitors
- Norepinephrine - antagonists and inhibitors
- Propranolol - pharmacology
- Rats - pharmacology
- Rats, Sprague-Dawley - pharmacology
- Stereoisomerism - pharmacology
- Vasoconstriction - drug effects
- Vasoconstrictor Agents - antagonists and inhibitors