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SHR Neuro Cancer Cardio Lipid Metab Microb
Indolfi, G; Gonzalez-Peralta, RP; Jonas, MM; Sayed, MH; Fischler, B; Sokal, E; Wirth, S; Nicastro, E, , Hepatology, Committee, of, the, ESPGHAN.
ESPGHAN recommendations on treatment of chronic hepatitis C virus infection in adolescents and children including those living in resource-limited settings.
J Pediatr Gastroenterol Nutr. 2024; 78(4): 957-972.
Doi: 10.1002/jpn3.12160
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- Abstract:
- Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide, with more than three million viraemic adolescents and children. Treatment of adults with HCV infection and HCV-related liver disease has advanced considerably thanks to development and improvements in therapy. Direct-acting antiviral regimens are safe and effective. Three regimens with pangenotypic activity (glecaprevir/pibrentasvir, sofosbuvir/velpatasvir and sofosbuvir/velpatasvir/voxilaprevir) and three regimens with genotype-specific activity (sofosbuvir/ribavirin, sofosbuvir/ledipasvir and elbasvir/grazoprevir) have been approved with age-specific limitation for treatment of children with chronic hepatitis C by the European Medicines Agency and the United States Food and Drug Administration. The World Health Organization has set the ambitious target to eliminate hepatitis C as a major public health threat by 2030 and based its actions against HCV on the large use of direct acting antivirals. These updated European Society for Pediatric Gastroenterology, Hepatology and Nutrition recommendations on treatment of hepatitis C describe the optimal therapeutic management of adolescents and children with HCV infection including specific indications for those living in resource-limited settings.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Child - administration & dosage
- Adolescent - administration & dosage
- Humans - administration & dosage
- Sofosbuvir - therapeutic use
- Hepatitis C, Chronic - drug therapy
- Antiviral Agents - therapeutic use
- Resource-Limited Settings - administration & dosage
- Drug Therapy, Combination - administration & dosage
- Hepacivirus - genetics
- Sulfonamides - pharmacology, therapeutic use
- Genotype - administration & dosage
- Hepatitis C - administration & dosage
- Treatment Outcome - administration & dosage
- Benzimidazoles - administration & dosage
- Benzopyrans - administration & dosage
- Carbamates - administration & dosage
- Heterocyclic Compounds, 4 or More Rings - administration & dosage
- Find related publications in this database (Keywords)
- efficacy
- position paper
- safety
- virological response