Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fontanesi, L; Scotti, E; Cisarova, K; Di, Battista, P; Dall'olio, S; Fornasini, D; Frabetti, A.
A missense mutation in the rabbit melanocortin 4 receptor (MC4R) gene is associated with finishing weight in a meat rabbit line.
Anim Biotechnol. 2013; 24(4): 268-77.
Doi: 10.1080/10495398.2013.781034
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Vizar Cisarova Katarina
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- Abstract:
- In this study we resequenced 1729 bp of the rabbit melanocortin 4 receptor (MC4 R) gene in 31 rabbits from different breeds/lines and identified ten polymorphisms: one was an indel and 9 were single nucleotide polymorphisms (SNPs). The indel and 5 SNPs were in the 5'-flanking region, 3 were synonymous SNPs and one was a missense mutation (c.101G>A; p.G34D), located in a conserved position of the extracellular tail of the MC4 R protein. The missense mutation was analyzed in a panel of 74 rabbits of different breeds and in 516 performance tested rabbits of a commercial paternal line under selection for growth efficiency. Association analysis indicated that rabbits with the less frequent genotype in this population (DD) had a lighter weight at 70 postnatal days than animals with genotype GD (P < 0.10) and animals with genotype GG (P < 0.05). This is the third study on candidate genes, after those on GH1 and IGF2 that reported a marker associated with finishing weight. Therefore, it seems that a candidate gene approach in rabbit based on previous information accumulated in other livestock species could be useful to identify genes explaining a fraction of variability of performance traits with potential application on rabbit breeding and selection.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence - administration & dosage
- Animals - administration & dosage
- Body Weight - genetics
- Computer Simulation - administration & dosage
- Female - administration & dosage
- Livestock - genetics
- Male - administration & dosage
- Meat - administration & dosage
- Molecular Sequence Annotation - administration & dosage
- Molecular Sequence Data - administration & dosage
- Mutation, Missense - administration & dosage
- Phenotype - administration & dosage
- Polymorphism, Single Nucleotide - administration & dosage
- Rabbits - administration & dosage
- Receptor, Melanocortin, Type 4 - genetics
- Find related publications in this database (Keywords)
- Association study
- Growth rate
- MC4R
- Meat rabbit
- SNP