Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Šimunić, E; Podgorski, II; Pinterić, M; Hadžija, MP; Belužić, R; Paradžik, M; Dončević, L; Balog, T; Kaloper, M; Habisch, H; Madl, T; Korać, A; Sobočanec, S.
Sirtuin 3 drives sex-specific responses to age-related changes in mouse embryonic fibroblasts.
Mech Ageing Dev. 2024; 222: 111996
Doi: 10.1016/j.mad.2024.111996
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Habisch Hansjörg
- Madl Tobias
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- Abstract:
- The aging process is a complex phenomenon characterised by a gradual decline in physiological functions and an increased susceptibility to age-related diseases. An important factor in aging is mitochondrial dysfunction, which leads to an accumulation of cellular damage over time. Mitochondrial Sirtuin 3 (Sirt3), an important regulator of energy metabolism, plays a central role in maintaining mitochondrial function. Loss of Sirt3 can lead to reduced energy levels and an impaired ability to repair cellular damage, a hallmark of the aging process. In this study we investigated the impact of Sirt3 loss on mitochondrial function, metabolic responses and cellular aging processes in male and female mouse embryonic fibroblasts (MEF) exposed to etoposide-induced DNA damage, which is commonly associated with cellular dysfunction and senescence. We found that Sirt3 contributes to the sex-specific metabolic response to etoposide treatment. While male MEF exhibited minimal damage suggesting potential prior adaptation to stress due to Sirt3 loss, female MEF lacking Sirt3 experienced higher vulnerability to genotoxic stress, implying a pivotal role of Sirt3 in their resistance to such challenges. These findings offer potential insights into therapeutic strategies targeting Sirt3- and sex-specific signalling pathways in diseases associated with DNA damage that play a critical role in the aging process.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Sirtuin 3 - metabolism
- Mice - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Fibroblasts - metabolism
- DNA Damage - administration & dosage
- Etoposide - pharmacology
- Aging - metabolism, physiology
- Mitochondria - metabolism
- Cellular Senescence - physiology, drug effects
- Sex Characteristics - administration & dosage
- Find related publications in this database (Keywords)
- Sirtuin 3
- Sex differences
- MEF
- Etoposide
- DNA damage
- Aging