Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Aschauer, S; Gouya, G; Klickovic, U; Storka, A; Weisshaar, S; Vollbracht, C; Krick, B; Weiss, G; Wolzt, M.
Effect of systemic high dose vitamin C therapy on forearm blood flow reactivity during endotoxemia in healthy human subjects.
Vascul Pharmacol. 2014; 61(1): 25-9.
Doi: 10.1016/j.vph.2014.01.007
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Klickovic Uros
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- Abstract:
- OBJECTIVE: Acute inflammation induced by administration of Escherichia coli lipopolysaccharide endotoxin (LPS) reduces plasma concentrations of vitamin C and impairs vascular endothelium-derived nitric oxide (NO) bioactivity. We tested the hypothesis that systemically administered high dose vitamin C restores the endogenous anti-oxidant potential and improves NO-dependent vasodilatation in the forearm vasculature. DESIGN & SETTING: 36 male subjects were enrolled in this balanced, placebo controlled cross-over study. Forearm blood flow (FBF) reactivity to acetylcholine (ACh) and glyceryl-trinitrate (GTN), a sensitive test for endothelial function, was assessed at baseline and 4h after LPS-administration (20 IU/kg i.v). The effect of two different doses of intravenous vitamin C (Vitamin C-Injektopas®), 320 mg/kg and 480 mg/kg over 2h, or placebo on forearm vascular function was studied after LPS. MAIN RESULTS: LPS caused transient flu-like symptoms, decreased plasma vitamin C concentrations and reduced the ACh-dependent increase in FBF by up to 76%. Vitamin C at a mean plasma concentration of 3.2 or 4.9 mmol/L restored the response to ACh compared to baseline. CONCLUSION: High dose systemic vitamin C recovers LPS-induced endothelium-dependent vasodilation in the forearm resistance vasculature. This provides a rationale for a further clinical study of the systemic vitamin C effect under inflammatory conditions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Ascorbic Acid - therapeutic use
- Cross-Over Studies - administration & dosage
- Double-Blind Method - administration & dosage
- Endotoxemia - drug therapy, physiopathology
- Forearm - blood supply
- Healthy Volunteers - administration & dosage
- Humans - administration & dosage
- Lipopolysaccharides - pharmacology
- Male - administration & dosage
- Regional Blood Flow - drug effects
- Find related publications in this database (Keywords)
- Vitamin C
- Inflammation
- Endotoxemia
- Endothelial dysfunction
- Forearm blood flow