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Selected Publication:
Stulnig, TM; Jürgens, G; Chen, Q; Moll, D; Schönitzer, D; Jarosch, E; Wick, G.
Properties of low density lipoproteins relevant to oxidative modifications change paradoxically during aging.
Atherosclerosis. 1996; 126(1):85-94
Doi: 10.1016%2F0021-9150%2896%2905896-0
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- Co-authors Med Uni Graz
- Jürgens Günther
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- Abstract:
- Atherosclerosis is a common problem among the elderly. Because lipid peroxidation is considered a contributor to the development of atherosclerosis, we compared oxidative properties of lipoproteins in an otherwise healthy (SENIEUR-classified) aged population (65-74 years) with young controls (18-30 years). Relative amounts of oxidatively altered low density lipoprotein (LDL), estimated by means of an antibody against LDL modified by 4-hydroxynonenal, a product of lipid peroxidation, were increased marginally in serum from the elderly (9.8 vs. 7.4%, P = 0.07). In contrast, isolated LDL from the elderly revealed a decreased susceptibility to in vitro oxidation: the lag time was increased (2.34 vs. 2.10 h, P < 0.01), and the maximal rate of LDL oxidation decreased (0.88 vs. 1.01 O.D./h, P = 0.001). However, there were no age-related changes in lipid composition of native LDL and consumption of fatty acids during in vitro oxidation. The serum concentrations of ascorbic acid and most lipophilic anti-oxidants (the latter expressed per g serum lipids) were significantly decreased in the elderly except tocopherols which tended to be higher. In conclusion, our data reveal paradox age-related alterations of LDL as to its behaviour in oxidation in vivo vs. in vitro.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Aging - blood
- Aldehydes - blood
- Antioxidants - analysis
- Arteriosclerosis - metabolism
- Ascorbic Acid - blood
- Fatty Acids - blood
- Female - blood
- Humans - blood
- Lipid Peroxidation - blood
- Lipoproteins, LDL - blood
- Male - blood
- Oxidation-Reduction - blood
- Thiobarbituric Acid Reactive Substances - analysis
- Vitamins - blood
- Find related publications in this database (Keywords)
- Atherosclerosis
- Low-Density Lipoproteins (LDL)
- Lipid Peroxidation
- Antioxidants
- Polyunsaturated Fatty Acids
- Aging
- Senieur Protocol