Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Balandin, D; Szulc, N; Bystranowska, D; Gasior-Glogowska, M; Kruszakin, R; Szefczyk, M.
Boosting stability: a hierarchical approach for self-assembling peptide structures
J MATER CHEM B. 2024;
Doi: 10.1039/d4tb01545b
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Balandin Denys
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- Abstract:
- The primary objective of this study was to implement a hierarchical approach to enhance the conformational stability of a selected group of peptides by incorporating trans-(1S,2S)-2-aminocyclopentanecarboxylic acid (trans-ACPC). The influence of residue mutation on the peptide structures was investigated using circular dichroism, analytical ultracentrifugation, and vibrational spectroscopy. The resulting nanostructures were examined via transmission electron microscopy. The incorporation of trans-ACPC led to increased conformational stability and self-assembling propensity in peptides containing constrained beta-amino acid residues. Our findings indicate that the nanostructure formation is influenced by all the positions within the coiled-coils.